DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Dlg2

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_006507830.1	Gene:	Dlg2 / 23859	MGIID:	1344351	Length:	1027	Species:	Mus musculus

Alignment Length:	881	Identity:	354/881 - (40%)
Similarity:	481/881 - (54%)	Gaps:	195/881 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 IQK--AHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSI 364
            :||  ..|||.|||:|..:|.:|:::.|:.|:::|:.||||.|||||||||||||:|||:..||.
Mouse     4 LQKEDTDRALSLLEEYCKKLRKPEEQLLKNAVKKVMSIFKSSLFQALLDIQEFYEVTLLNSQKSC 68

  Fly   365 QQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENA---------------KEPTVEQQQKQQ 414
            :||..|...:|.||||    ..:.|:.|..::..:|:|               ||....:.:.::
Mouse    69 EQKIEEANHVAQKWEK----TLLLDSCRDSLQKSSEHASCSGPKENALYIEQNKENQCSENETEE 129

  Fly   415 QAQQRSSRSPQQ----QNP-------------QQQQG----------------------SKSRSG 440
            :..|...:.|.|    :.|             |.:.|                      .|:.|.
Mouse   130 KTCQNQGKCPAQNCSVEAPTWMPVHHCTKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSEKNLSQ 194

  Fly   441 SQTVNG---------------------------------DDSWLYEDIQLERGNSGLGFSIAGGT 472
            .:.|:|                                 :..:.:|:|.||||||||||||||||
Mouse   195 IENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGT 259

  Fly   473 DNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHV 537
            ||||||.|..|:|||:|.|||||.||||.:||.|:.||:|.|.:|.|:.||:|||:||::|:|:|
Mouse   260 DNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 324

  Fly   538 KRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKL 602
            :|:|....|                   |:||.|.||.||||||||||:|||||||||.|||||:
Mouse   325 RRRRPILET-------------------VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKI 370

  Fly   603 MDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGK---------- 657
            :||||||.||||.:||:|:.|    :..:||.||||.|||.||:.:|.|.|.:||
Mouse   371 IDGGAAQKDGRLQVGDRLLMV----NNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPY 431

  Fly   658 -TQHLTTSAS--------GGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATP------MVNS 707
             ...:|.|.|        .|..|.|.....|........:...:..:.:..:..|      .||.
Mouse   432 GPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLGEDDYTRPPEPVYSTVNK 496

  Fly   708 QSTEPGS--RYASTNVLAAVPPGTP--------------------------------RAVSTEDI 738
            ...:|.|  .|:......:....||                                ||:|.|.
Mouse   497 LCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEG- 560

  Fly   739 TREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATH 803
              |||.:.:.||..||||||||||||:||:||||||||||||..||:||||:||||.::|..|:|
Mouse   561 --EPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 623

  Fly   804 EEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAA--LGAGGSGTLLRTTQKRSLYVRAL 866
            |:||.|||.:|..||::|||:||:|.||||:|.:|::|..  ..:.|||: |||.|||||||||:
Mouse   624 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGS-LRTNQKRSLYVRAM 687

  Fly   867 FDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRAR 931
            ||||.::|.||||:||.||:||||||.|||||||||||||..|.:.|::|::|||||.|||.|||
Mouse   688 FDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERAR 752

  Fly   932 DRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANA 996
            .::|||.......::  |.|..|::||:|.|||||||.|::::..::.||.|..:.....|..::
Mouse   753 LKTVKFNAKPGVIDS--KGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPEQHVSSNASDSESS 815

  Fly   997 EGGEIIYRVELPDMEQITLIY--LENNDADYRKSSI 1030
            ..|:          |.:.|.|  :...:.:|.:..|
Mouse   816 CRGQ----------EDLILSYEPVTRQEINYTRPVI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	33/57 (58%)
		PDZ	454..540	CDD:214570	57/85 (67%)
		PDZ_signaling	566..655	CDD:238492	58/88 (66%)
		PDZ_signaling	742..820	CDD:238492	52/77 (68%)
		SH3_DLG-like	862..922	CDD:212795	41/59 (69%)
Dlg2	XP_006507830.1	L27_1	4..63	CDD:370268	33/58 (57%)
		MAGUK_N_PEST	158..240	CDD:371162	6/81 (7%)
		PDZ_signaling	241..325	CDD:238492	56/83 (67%)
		PDZ_signaling	334..419	CDD:238492	58/88 (66%)
		PDZ_assoc	421..488	CDD:371157	9/66 (14%)
		PDZ_signaling	562..640	CDD:238492	52/77 (68%)
		SH3_DLG2	677..750	CDD:212965	52/72 (72%)
		Guanylate_kin	836..1014	CDD:366206	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836161
Domainoid	1	1.000	311	1.000	Domainoid score	I1317
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	893	1.000	Inparanoid score	I387
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm42342
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3167
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.700