Protein Alignment dlg1 and PDZD2

DIOPT Version :9

• Sequence 1: NP_001162718.1
• Gene: dlg1 / 32083
• FlyBaseID: FBgn0001624
• Length: 1030
• Species: Drosophila melanogaster
• Sequence 2: XP_005248326.1
• Gene: PDZD2 / 23037
• HGNCID: 18486
• Length: 2873
• Species: Homo sapiens
• Alignment Length: 1087
• Identity: 217/1087 - (19%)
• Similarity: 358/1087 - (32%)
• Gaps: 380/1087 - (34%)

  Fly   115 ETVTEPDPEPPK---CPTSLRDSV--RESVECFYSAQDLLEYGHMLSSTSMVRTPDVESGYFEKS 174
            |:...||..||:   |...|...:  .|:|.        |.:|::          .|...|.||.
Human    54 ESTVPPDHSPPEMEICTVYLTKELGDTETVG--------LSFGNI----------PVFGDYGEKR 100

  Fly   175 ESDASRDEWEGP----------------SSSSSGAARCR----LLSG--ISGLSVSSSSRHSAEG 217
            .....|...:||                .:..||..|.|    .|:|  :.|:.||.:| :.||.
Human   101 RGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGAS-YLAEQ 164

  Fly   218 -------LRMELSRFRTMIETLERESLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGS 275
                   ..:.|.||:           .|:.|.....:.:.::|.......:.|...:.|..
Human   165 CWNGGFIYLIMLRRFK-----------HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKR--- 215

  Fly   276 ERGFWSTIFGQAGLAISQDEEERIADIQKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKS 340
                 :..||    .||:....:..:..|.....|:..|....|
Human   216 -----TRKFG----VISRPPANKAPEESKGSAGCEVSSDPSTEL--------------------- 250

  Fly   341 RLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKE- 404
                                                   ::|...::.:....::|:..::.||
Human   251 ---------------------------------------ENGPDPELGNGHVFQLENGPDSLKEV 276

  Fly   405 --PTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYEDI------QLERGN 461
              |.:|:.:..:..:.|..::.........:...|:.|.......|....|::      :|.:.:
Human   277 AGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKES 341

  Fly   462 SGLGFSIAGGTD---NPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAV 523
            .|||..::||..   :||     :|.:|::..||||..|||||:.|.::.:|...:|.:.|..||
Human   342 DGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAV 401

  Fly   524 DALKKAGNVVKLHVKRK------------------------------------------------ 540
            ..|:.|..:|:|.|..|
Human   402 AILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSV 466

  Fly   541 -------------------RGTATTPAAGS---------------------------AAGDAR-- 557
                               :|...:|..||                           ..||.|
Human   467 QRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIR 531

  Fly   558 -----------------DSAASG--------------------------PKVIE-IDLVK-GGKG 577
                             ||:::.                          |.||. |.|.| .|||
Human   532 MLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKG 596

  Fly   578 LGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVA 642
            |||||||  |...|.|..||:|..:...|:|..||||..||:::.|  ||..  ::.:|.:.|:.
Human   597 LGFSIAG--GRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDV--NGIP--IKGLTFQEAIH 655

  Fly   643 TLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNS 707
            |.|.|...:.::..:|:.::.|                       .:...:..|..:.|:|..|:
Human   656 TFKQIRSGLFVLTVRTKLVSPS-----------------------LTPCSTPTHMSRSASPNFNT 697

  Fly   708 Q--STEPGSRYASTNVLAAVPPG-TPRAVSTEDITREPRTITIQKGPQGLGFNIVGG------ED 763
            .  ::..||...|::.|....|| ..|.|....:.:|||.        |||   :|.      ..
Human   698 SGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRV--------GLG---IGACCLALENS 751

  Fly   764 GQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQAL-KTSGGVVTLLAQYRP-- 825
            ..|||:..:..|..|.:.|.|.||||:|.||:||:.||...:....| |...|.|.|:....|
Human   752 PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNP 816

  Fly   826 ----EEYNRFEARIQELKQQAALGAGGSGTLLRT---TQKRSLY----VRALFDYDPNRDDGLPS 879
                :|.:...||....:.:.|..:.|.||.|::   .:|.||.    :...|.:|
Human   817 KVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHD--------- 872

  Fly   880 RGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAAN 944
              :|....|.: |..:.|::    ....|.:..|:..:.||....:...:.|..|:...|...|:
Human   873 --VPGPLSDFM-VAGSEDED----HPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTLGSHRAS 930

  Fly   945 NNLDKQSTLDRKKK--NFTFSRKFPFMKSRD----EKNEDGSDQEPF 985
            ....||.|:.|:..  ....:.:.|.::.|.    :.| |.||:|.|
Human   931 GLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDAN-DASDEEEF 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	4/55 (7%)
		PDZ	454..540	CDD:214570	30/94 (32%)
		PDZ_signaling	566..655	CDD:238492	37/90 (41%)
		PDZ_signaling	742..820	CDD:238492	28/84 (33%)
		SH3_DLG-like	862..922	CDD:212795	10/63 (16%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492	29/85 (34%)
		PDZ_signaling	589..670	CDD:238492	34/86 (40%)
		PDZ_signaling	726..810	CDD:238492	31/94 (33%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810