DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and magu-1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_497201.1	Gene:	magu-1 / 190302	WormBaseID:	WBGene00021914	Length:	567	Species:	Caenorhabditis elegans

Alignment Length:	317	Identity:	83/317 - (26%)
Similarity:	131/317 - (41%)	Gaps:	78/317 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   675 SGQQLSQSQ------SQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAA--VP--PGT 729
            |.|:|||:.      |.:.:|..|..|.       ::|....: |..:|:..:.|.  .|  |..
Worm    60 SFQELSQNVLDDWDISNIKSSSVQQLVE-------LLNLPRVQ-GVLWAAQEISAGRFAPQLPDV 116

  Fly   730 PRAVSTEDITREPRTITIQKG-PQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSV 793
            |..|..:|.........:::| |.|.......|:    :||:.|:|.|.||....::.||::|.|
Worm   117 PFEVDEDDGVAVKIVRIVRRGEPLGATIKCERGK----VYVARIMANGVADRSGCIQEGDRVLEV 177

  Fly   794 NNVNLTHATHEEAAQAL-KTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQ 857
            |.:.:......|..:.| |...|::|.  :..|.|.|      |:|||:               :
Worm   178 NGITVADKEPREIVKLLDKCDNGIITF--KLIPAEIN------QKLKQK---------------K 219

  Fly   858 KRSLYVRALFDYDPNRD--DGLPSRGLPFKHGDILHVTNASDDEWWQARRV-LG----------- 908
            ....|.||||||||.:|  ...|...:.|:.||||.:.:..|..|||.|:: .|
Worm   220 SSHRYARALFDYDPWQDKRHPCPEAAISFRGGDILEILDEKDQYWWQTRKIGFGALARRKESHDD 284

  Fly   909 DNEDE--QIGIVPSKRRWERKMRARDRSVKFQGHAAAN---NNLDKQSTLDRKKKNF 960
            :|.|:  ::|:|||:  |          ::.|.....|   .:.|.||.|:..|..|
Worm   285 ENRDDSKKVGLVPSE--W----------LQCQSEIPENGIDTSDDFQSFLENHKGRF 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	21/79 (27%)
		SH3_DLG-like	862..922	CDD:212795	28/75 (37%)
magu-1	NP_497201.1	PDZ_signaling	128..201	CDD:238492	19/76 (25%)
		SH3_MPP	224..300	CDD:212796	28/77 (36%)
		Guanylate_kin	348..550	CDD:279019
		NK	353..543	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810