DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and magu-3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_491260.2	Gene:	magu-3 / 183676	WormBaseID:	WBGene00016841	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	74/328 - (22%)
Similarity:	121/328 - (36%)	Gaps:	69/328 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 LSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQ 678
            :|..|:|..:|:|.  :||....|.| :..:::|..|    .||.|...::.|.|.......|::
Worm     1 MSEEDELSQLRSNA--ENLSRCLHVL-LEKIENIEKK----NGKEQDADSTKSNGTSSSNKDGKE 58

  Fly   679 LSQSQSQLATSQSQSQVHQQQHATPMVN-SQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREP 742
            ..:          |.::.::....|... .:.|....|..:|....|:....|....| .|.|..
Worm    59 KFE----------QVEIEEKTEIDPKTGLKKRTIVTERVLTTKTFHALALDGPSPTMT-PILRSS 112

  Fly   743 RTITIQKGPQGLGFNIVGGEDGQGIYVSFIL------------AGGPADLGSELKRGDQLLSVNN 795
            .|......|               |:.|.||            ||....:..| |.|.||: |..
Worm   113 GTKNHNYAP---------------IHQSAILLPQYQSRKTTVDAGQLTQVEVE-KHGGQLV-VTK 160

  Fly   796 VNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRS 860
            :|      |::...|| .|.|:|.:.  ..:.|  |.|.|:.||.:..|....:|.......
Worm   161 IN------EKSNYDLK-PGDVITQVD--GKDVY--FRADIENLKGKVELTVEPAGIHCAPAN--- 211

  Fly   861 LYVRALFDYDPNRDDGLPSRGLPFK--HGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRR 923
             :.|....|..:.|...|...|..:  .||::.:. :.|::|.|.|: |||.  .|:|.:|:...
Worm   212 -FHRVQDTYSSHIDVDRPCLWLDLEVNPGDVIQIL-SKDEKWMQVRK-LGDL--TQVGYLPTSLT 271

  Fly   924 WER 926
            .|:
Worm   272 MEK 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492	11/40 (28%)
		PDZ_signaling	742..820	CDD:238492	21/89 (24%)
		SH3_DLG-like	862..922	CDD:212795	17/61 (28%)
magu-3	NP_491260.2	PDZ	147..204	CDD:381812	20/69 (29%)
		SH3	218..268	CDD:388381	15/53 (28%)
		Guanylate_kin	282..464	CDD:366206
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810