DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and DLG2

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_016872743.1	Gene:	DLG2 / 1740	HGNCID:	2901	Length:	1039	Species:	Homo sapiens

Alignment Length:	885	Identity:	358/885 - (40%)
Similarity:	484/885 - (54%)	Gaps:	202/885 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 RALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALL-------------DIQEFYELTLL 358
            |||.|||:|..:|.:|:::.|:.|:::|:.||||.||||||             :||||||:|||
Human    10 RALSLLEEYCKKLRKPEEQLLKNAVKKVMGIFKSSLFQALLGQSKTQDQGQHQWNIQEFYEVTLL 74

  Fly   359 DDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIE-SDTENAKE--PTVEQQQKQQQAQ--- 417
            :..||.:||..|..|:..||||........|..:...| :|...:||  ..:||.::.|..:
Human    75 NSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKSSELTDCSGSKENASCIEQNKENQSFENET 139

  Fly   418 -----QRSSRSPQQ--------------------------------------QNPQQQQGS-KSR 438
                 |...|.|.|                                      :.|:....| |:.
Human   140 DETTTQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNL 204

  Fly   439 SGSQTVNG---------------------------------DDSWLYEDIQLERGNSGLGFSIAG 470
            |..:.|:|                                 :..:.:|:|.||||||||||||||
Human   205 SQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAG 269

  Fly   471 GTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL 535
            ||||||||.|..|:|||:|.|||||.||||.:||.|:.||:|.|.:|.|:.||:|||:||::|:|
Human   270 GTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRL 334

  Fly   536 HVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVT 600
            :|:|:|....|                   |:||.|.||.||||||||||:|||||||||.||||
Human   335 YVRRRRPILET-------------------VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVT 380

  Fly   601 KLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGK-------- 657
            |::||||||.||||.:||:|:.|    :..:||.||||.|||.||:.::.|.|.:||
Human   381 KIIDGGAAQKDGRLQVGDRLLMV----NNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTD 441

  Fly   658 ---TQHLTTSAS--------GGGGGGLS--------SGQQLSQSQSQLATSQSQSQVHQQQHATP 703
               ...:|.|.|        .|..|.|.        |..:.|.....:......::..:..::|
Human   442 PYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYST- 505

  Fly   704 MVNSQSTEPGS-RYAS-----TNVLAAVP---------PGT-------------------PRAVS 734
             ||....:|.| |:.|     .:.|.:.|         |.:                   .||||
Human   506 -VNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVS 569

  Fly   735 TEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLT 799
            .|.   |||.:.:.||..||||||||||||:||:||||||||||||..||:||||:||||.::|.
Human   570 LEG---EPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 631

  Fly   800 HATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAA--LGAGGSGTLLRTTQKRSLY 862
            .|:||:||.|||.:|..||::|||:||:|.||||:|.:|::|..  ..:.|||: |||.||||||
Human   632 GASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGS-LRTNQKRSLY 695

  Fly   863 VRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERK 927
            |||:||||.::|.||||:||.||:||||||.|||||||||||||:.:.:.|::|::|||||.|||
Human   696 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERK 760

  Fly   928 MRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQD 992
            .|||.::|||.......::  |.|..|::||:|.|||||||.|::::..::.||.|..:
Human   761 ERARLKTVKFNAKPGVIDS--KGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPEQHV------ 817

  Fly   993 DANAEGGEIIYRVELPDMEQITLIY--LENNDADYRKSSI 1030
            .:||...|..||    ..|.:.|.|  :...:.:|.:..|
Human   818 SSNASDSESSYR----GQEDLILSYEPVTRQEINYTRPVI 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	30/64 (47%)
		PDZ	454..540	CDD:214570	57/85 (67%)
		PDZ_signaling	566..655	CDD:238492	57/88 (65%)
		PDZ_signaling	742..820	CDD:238492	52/77 (68%)
		SH3_DLG-like	862..922	CDD:212795	40/59 (68%)
DLG2	XP_016872743.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146066
Domainoid	1	1.000	310	1.000	Domainoid score	I1328
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	892	1.000	Inparanoid score	I392
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3167
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.700