DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and DLG1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_004078.2	Gene:	DLG1 / 1739	HGNCID:	2900	Length:	926	Species:	Homo sapiens

Alignment Length:	815	Identity:	355/815 - (43%)
Similarity:	475/815 - (58%)	Gaps:	167/815 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 QKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSI-QQ 366
            |...|||.|||:|.::||:.:||.||.:|||||.||:|.|||||:|||||||:||||:.|.| :.
Human     6 QDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRS 70

  Fly   367 KTAETLQIATKWEKDGQAVKIADNQRMRIESDT-ENAKEPTVEQQQKQQQ---AQQRSSRS---- 423
            |.:|.:|....||       |:......:.|:| .::..|:||:.:.|.:   .|:..|..
Human    71 KPSEPIQPVNTWE-------ISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNE 128

  Fly   424 ----------------------------------------------------------------P 424
                                                                            |
Human   129 VIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIP 193

  Fly   425 QQQNPQQQQGSKSRSGSQTVNGDDS-WLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKL 488
            |...|.....:.|......|||.|: :.||:|.||||||||||||||||||||||.|:||:|||:
Human   194 QANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKI 258

  Fly   489 ISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAA 553
            |:|||||.||||.:||.|:.||:|.|.||.|:.||:|||:||::|:|:|||::..:
Human   259 ITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS--------- 314

  Fly   554 GDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGD 618
                      .|::||.|:||.||||||||||:|||||||||.|||||:::||||..||:|.|||
Human   315 ----------EKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGD 369

  Fly   619 KLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQ 683
            ||:||    :...||.||||.||..||:.:|.|.|.:.|    .||.....|
Human   370 KLLAV----NNVCLEEVTHEEAVTALKNTSDFVYLKVAK----PTSMYMNDG------------- 413

  Fly   684 SQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTP-------RAVSTED-ITR 740
                            :|.|.:.:.|::|...:.|.:......|.:|       :||..:| |||
Human   414 ----------------YAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITR 462

  Fly   741 EPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEE 805
            |||.:.:.:|..||||||||||||:||::|||||||||||..||::||:::|||:|:|..|:||:
Human   463 EPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527

  Fly   806 AAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALG--AGGSGTLLRTTQKRSLYVRALFD 868
            ||.|||.:|..||::||||||||:||||:|.:|::|....  :.|||: |||:||||||||||||
Human   528 AAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGS-LRTSQKRSLYVRALFD 591

  Fly   869 YDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDR 933
            ||..:|.||||:||.||.||||||.|||||||||||:|..|.|.:::|::|||||.|:|.|||.:
Human   592 YDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLK 656

  Fly   934 SVKFQGHAAANNNLDK-QSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAE 997
            :|||.     :...|| ||..|::|||. |||||||.|::|:..::.||.:..:      .:||.
Human   657 TVKFN-----SKTRDKGQSFNDKRKKNL-FSRKFPFYKNKDQSEQETSDADQHV------TSNAS 709

  Fly   998 GGEIIYRVELPDMEQITLIY--LENNDADYRKSSI 1030
            ..|..||    ..|:..|.|  :...:.:|.:..|
Human   710 DSESSYR----GQEEYVLSYEPVNQQEVNYTRPVI 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	36/55 (65%)
		PDZ	454..540	CDD:214570	60/85 (71%)
		PDZ_signaling	566..655	CDD:238492	56/88 (64%)
		PDZ_signaling	742..820	CDD:238492	48/77 (62%)
		SH3_DLG-like	862..922	CDD:212795	41/59 (69%)
DLG1	NP_004078.2	L27_1	2..62	CDD:370268	36/55 (65%)
		MAGUK_N_PEST	106..223	CDD:371162	12/116 (10%)
		PDZ_signaling	224..308	CDD:238492	58/83 (70%)
		PDZ_signaling	317..403	CDD:238492	56/89 (63%)
		PDZ_assoc	404..465	CDD:371157	18/93 (19%)
		PDZ	463..547	CDD:214570	52/83 (63%)
		SH3_DLG1	582..648	CDD:212964	47/65 (72%)
		Guanylate_kin	735..913	CDD:366206	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146064
Domainoid	1	1.000	310	1.000	Domainoid score	I1328
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20869
Inparanoid	1	1.050	892	1.000	Inparanoid score	I392
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm40275
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	1	1.100	-	-	O	PTHR23119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3167
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800