Protein Alignment dlg1 and Card14

DIOPT Version :10

• Sequence 1: NP_001162718.1
• Gene: dlg1 / 32083
• FlyBaseID: FBgn0001624
• Length: 1030
• Species: Drosophila melanogaster
• Sequence 2: XP_006532429.1
• Gene: Card14 / 170720
• MGIID: 2386258
• Length: 1029
• Species: Mus musculus
• Alignment Length: 1144
• Identity: 211/1144 - (18%)
• Similarity: 354/1144 - (30%)
• Gaps: 367/1144 - (32%)

  Fly    11 KSSDPNEGLLSSDDKTFHDDD---------EPAEDSSPADDEEEPEEEECL----------LPQK 56
            |:...|..:...:...||:.|         ...:.|:.:...|..:..|||          |.|:
Mouse    78 KARGKNGAIAFLESLKFHNPDVYTLVTGLQSDIDFSTFSGLMETSKLTECLAGAISSLQEELAQE 142

  Fly    57 KAQ-----IRCDQDQPPLVVLVQPSAEAIEVRQ-EIDDTNPVAVAAKASDMDGDSQLEVMEHQME 115
            |||     .||.|.:..| .|.:..||.:  || |:|.:.              .:.||..|..|
Mouse   143 KAQKEVLLRRCQQLKERL-GLAEAHAEGL--RQLEVDHSR--------------MKREVSTHFHE 190

  Fly   116 TVTEPDPEPPKCPTSLRDSVRE----SVECFYSAQDLLEYGHMLSSTSMVRTPDVESGYFEKSES 176
            .:...| |.........:::||    :..|....::|......|...|:|.:.:.||.  |:|..
Mouse   191 VLKLKD-EMLNLSLHYSNALREKELAATRCHSLQEELYLVKQELQRASLVSSCERESR--ERSLK 252

  Fly   177 DASRDEWEGPSSSSSGAARCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIETL-ERESLEKS 240
            .||..|.:|                           .....|:.|..:.|:|..:| |::.||:|
Mouse   253 MASNLEPQG---------------------------EELNRLKEENEKLRSMTFSLVEKDILEQS 290

  Fly   241 QSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWSTIFGQAGLAISQDEEERIADIQKA 305
            ..|.:     ::|.:...|.|.......:...|  ::.:|            :::|:.:...:|.
Mouse   291 LDEAR-----ESKQELVDRIHSLRERAVAAERQ--QKQYW------------EEKEQTLLQFRKT 336

  Fly   306 HRALEL-------LEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELT--LLDDS 361
            ....||       |:...|.|.:.:|:|. .|.:|.......||.:.....:..:|||  :.:..
Mouse   337 QVDCELYKEKMTMLQGQVAELQKERDQAY-TARDRAQMEISQRLVEKDALRRRVFELTEQVCELR 400

  Fly   362 KSIQQKTAETLQIATKWEKDGQAVKIADNQRM--------------RIESDTENAKEPTVEQQQK 412
            ..:::..||. ....|.|...:.:.:...||:              .:.|.||:.....:.....
Mouse   401 TQLRRLQAEA-PGGPKQEAGARELCLRGKQRLVRMHAVCPPDDSDCSLLSSTESRLWWDLNSTSS 464

  Fly   413 QQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHI 477
            ::|.....|.||.   |..||....|.....:...:|..:.::        |...:.|.|.:
Mouse   465 REQMDSFRSSSPM---PPSQQSLYKRVAEDFLEDPESLSFPEV--------LEMRLQGATVD--- 515

  Fly   478 GTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVV--KLHVKRK 540
            .|||.:....:  .||..:....|:.....|:|....:.:|..|:|...::....:  ::.|...
Mouse   516 DTDTDLEFEMI--DGADLSQTEDSLQGSSRSLNVSERLCLPAHSSVPVRRRPARKILSQVTVLAF 578

  Fly   541 RGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDG 605
            :|.|.....|...|:.                                      .||::.::..|
Mouse   579 QGDALLEQIGVIGGNL--------------------------------------TGIFIHRVTPG 605

  Fly   606 GAAQVDGRLSIGDKLIAVRTNGSEKN----LENVTHELAVATLKSITDKV------------TLI 654
            .||. :..|..|.:::.|....::.:    |||.|.|.||..|:.:....            .||
Mouse   606 SAAD-EMALRPGTQIMMVDYKPTKPSLRATLENTTLEQAVGLLRRVNGSCYLSVKINTEGYKNLI 669

  Fly   655 IGKTQHLTTSASG-----------GGGGGLSS--GQQLSQSQSQLATSQSQSQVHQQQHATPMVN 706
            ......:.||...           ||.|.|.:  ...|..:.:..   |.:|..| ..|..| ..
Mouse   670 QDLDAKVVTSGDSFYIRVNLAMQRGGDGELQTHCNDILHVTDTMF---QGRSCWH-AHHVNP-YT 729

  Fly   707 SQSTEPGS----RYASTNVLAAVPPGTPRAVSTEDI-------TREPRT----ITIQKGPQGLGF 756
            .:..|||:    ..|...:||.:...|.|......:       .|.|.|    :::.|.|
Mouse   730 MKDMEPGTIPNYSQAQQQLLALIQDMTQRCTVPRKVGHLVLLGHRAPFTLSTHLSLSKPP----- 789

  Fly   757 NIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNV---NLTHATHEEAAQALKTSGG--- 815
                              |||..|       .:::||:..   .||.:..:....:.|..||
Mouse   790 ------------------GGPQKL-------VRIVSVDKAAVSPLTSSFDQSQWDSGKEEGGPSV 829

  Fly   816 -----------VVTLLAQYRPEE------YNRFEARI--------QELKQQAALGAGGSGTLLRT 855
                       ..||:..:||..      ..|...||        |..||.:|
Mouse   830 CFWSESCFTLAPYTLVHPHRPARPRPVLFVPRLVGRILGKKLCLLQGFKQCSA------------ 882

  Fly   856 TQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEW--WQARRVLGD--NEDEQIG 916
                        :|                         .|.:|:  |..|   ||  .|.|.||
Mouse   883 ------------EY-------------------------LSQEEYATWSQR---GDIIQEGESIG 907

  Fly   917 IVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFM-----------K 970
                ...|..: .|.:..:....||..:..||....|.|..       .||.:           |
Mouse   908 ----DHHWITR-HAVESLMNMSTHALLDVRLDSVRVLHRMD-------MFPIIIHVSVNEKTAKK 960

  Fly   971 SRDEKNEDGSDQEPFMLCYTQDDANAEGGEIIYRVELPD 1009
            .|...:..||.:|.|:....|::...:....:|....||
Mouse   961 LRKGLHRLGSSEEQFLEVARQEEGELDRVPCLYSSLAPD 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..361	CDD:462665	15/66 (23%)
		PDZ1_Dlg1-2-4-like	452..540	CDD:467206	15/89 (17%)
		PDZ2_Dlg1-2-4-like	568..656	CDD:467207	18/103 (17%)
		PDZ3_Dlg1-2-4-like	741..831	CDD:467257	19/116 (16%)
		SH3_DLG-like	862..922	CDD:212795	11/63 (17%)
Card14	XP_006532429.1	DD	19..104	CDD:472698	5/25 (20%)
		SMC_prok_B	135..>409	CDD:274008	68/340 (20%)
		PDZ_CARD11_CARD14-like	575..649	CDD:467218	21/112 (19%)
		SH3	684..745	CDD:473055	13/65 (20%)
		NK	<884..1008	CDD:450170	31/156 (20%)