DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and Guk1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_032219.2	Gene:	Guk1 / 14923	MGIID:	95871	Length:	219	Species:	Mus musculus

Alignment Length:	157	Identity:	31/157 - (19%)
Similarity:	51/157 - (32%)	Gaps:	38/157 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DPNEGLLSSDDKTFHDDDEPAEDSSPADDEEEPEEEECLLPQKKAQIRCDQ-------------- 64
            :|..|.....|..|...:....|.:..|..|..|....|....|..:|..|
Mouse    63 NPRPGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQG 127

  Fly    65 -------DQPPLVVLVQ-PSAEAIEVRQEIDDTNPVAVAAKASDMDGDSQLEVMEHQMETVTEP- 120
                   |..|:.:.|| ||.:.:|.|..:.:|......||        :|......||:..||
Mouse   128 VRSIKKTDLCPIYIFVQPPSLDVLEQRLRLRNTETEESLAK--------RLAAARTDMESSKEPG 184

  Fly   121 -------DPEPPKCPTSLRDSVRESVE 140
                   :.:..|...:|:.::.|.::
Mouse   185 LFDLVIINDDLDKAYATLKQALSEEIK 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492
		SH3_DLG-like	862..922	CDD:212795
Guk1	NP_032219.2	Guanylate_kin	24..209	CDD:279019	30/153 (20%)
Guk1	NP_032219.2	guanyl_kin	26..208	CDD:213788	30/152 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810