DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Mpp3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_446120.1	Gene:	Mpp3 / 114202	RGDID:	620015	Length:	585	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	81/289 - (28%)
Similarity:	126/289 - (43%)	Gaps:	52/289 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 LSSGQQLSQ---SQSQLATSQSQSQVHQQQHATP------MVNSQSTEPGSRYASTNVLAAVPPG 728
            |.|...|::   .:.|.|:..|..:...|..:||      ||:       ...|..|....:||
  Rat    65 LHSAMALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVH-------DTVAQKNFDPVLPP- 121

  Fly   729 TPRAVSTEDITREP-RTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLS 792
            .|..:. ||...|. :.:.:.|..:.||..|...|....:.|:.|:.||.||....:..||:|..
  Rat   122 LPDNID-EDFEEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELRE 185

  Fly   793 VNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQ 857
            ||.:.:.|...:|.:|.|..|.|.:||......:|.:||                         :
  Rat   186 VNGITVLHKRPDEISQILAQSQGSITLKIIPATQEEDRF-------------------------K 225

  Fly   858 KRSLYVRALFDYDPNRDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPS 920
            :..:::||||.|||..|..:|.:  ||||:...:|.|.:..|..||||:|| ||. :.:.|::||
  Rat   226 ESKVFMRALFHYDPREDRAIPCQEAGLPFQQRQVLEVVSQDDPTWWQAKRV-GDT-NLRAGLIPS 288

  Fly   921 KRRWERKMRARDRSVKFQGHAAANNNLDK 949
            |:..||::..|    :..|...:..||.|
  Rat   289 KQFQERRLSYR----RTTGTIPSPQNLRK 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	23/78 (29%)
		SH3_DLG-like	862..922	CDD:212795	27/61 (44%)
Mpp3	NP_446120.1	L27	12..64	CDD:197794
		L27	71..121	CDD:197794	11/56 (20%)
		PDZ_signaling	135..215	CDD:238492	24/79 (30%)
		SH3_MPP3	230..291	CDD:212972	28/62 (45%)
		GuKc	395..571	CDD:214504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810