DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Card11

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_780571.2	Gene:	Card11 / 108723	MGIID:	1916978	Length:	1154	Species:	Mus musculus

Alignment Length:	920	Identity:	171/920 - (18%)
Similarity:	308/920 - (33%)	Gaps:	299/920 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ESGYFEKSESDASRDEW-EGPSSSSSGAARCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIE 230
            |..|..|.|.|:..||. :....:.:.|.|...||....::|..|     ..|::|:.:.:..:.
Mouse   178 ERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRS-----RDLQLEIDQLKHRLN 237

  Fly   231 TLERE-SLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWSTIFGQAGLAISQD 294
            .:|.| .||::||   ||.|:..:.:|: :..|.:...|:...:...:...|.|  |||.....|
Mouse   238 KMEEECKLERNQS---LKLKNDIENRPR-KEQVLELERENEMLKTKIQELQSII--QAGKRSLPD 296

  Fly   295 EEERIADIQKAHRALELLED--------YHAR-------------LSEPQDRALRIA-IERVIRI 337
            .::.|.||.: |...|.|||        |:.:             |.|.:|..|:.: :.:...:
Mouse   297 SDKAILDILE-HDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEM 360

  Fly   338 FKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIAD----NQRMRIESD 398
            :|.|:...:|.::   |:....|.....:..|:|.......|||....:|.:    |..||||.
Mouse   361 YKHRMNTVMLQLE---EVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEM- 421

  Fly   399 TENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQ--------QQQGSKS-RSGSQTVNGDDSWLYED 454
              ..:|..:...:.:.:...:.:.|..|..|:        |..|..| |:..|  ..|||...|:
Mouse   422 --VRREACIVNLESKLRRLSKDNGSLDQSLPRHLPATIISQNLGDTSPRTNGQ--EADDSSTSEE 482

  Fly   455 ----------------------IQLERGNSGLG------FSIAGGTDNPHIGTDTSIYITKLISG 491
                                  |||:|..|.:.      |.:.|..::...|:.:|.....:.|.
Mouse   483 SPEDSKYFLPYHPPRRRMNLKGIQLQRAKSPISMKQASEFQVKGHEEDFTDGSPSSSRSLPVTSS 547

  Fly   492 GAAAAD--GRLSINDIIVSV--NDVSVV-----DVPHASAVDALKKAGNVVKLHVKRKRGTATTP 547
            .:....  .|.||..|....  || |:|     |.||.|.|:
Mouse   548 FSKMQPHRSRSSIMSITAEPPGND-SIVRRCKEDAPHRSTVE----------------------- 588

  Fly   548 AAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDG 612
                     .|:.:.|...:::|                ...|                     .
Mouse   589 ---------EDNDSCGFDALDLD----------------DENH---------------------E 607

  Fly   613 RLSIGDKLIAVRTNGSEKNLENV-THELAVATLKSITDKVTLIIGK---TQHLTTSASGGGGGGL 673
            |.|.|..  ::.::.|....|.: .::|         ::|.|::.|   .:....|.:.||
Mouse   608 RYSFGPP--SIHSSSSSHQSEGLDAYDL---------EQVNLMLRKFSLERPFRPSVTSGG---- 657

  Fly   674 SSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDI 738
                                            :.:.|.|..::.:.|
Mouse   658 --------------------------------HVRGTGPLVQHTTLN------------------ 672

  Fly   739 TREPRTITIQKGPQGL--GFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSV-------- 793
                        ..||  ...::|| :.:|.::..:..|..|:... |:.|.|||.:
Mouse   673 ------------GDGLITQLTLLGG-NARGSFIHSVKPGSLAERAG-LREGHQLLLLEGCIRGER 723

  Fly   794 NNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQK 858
            .:|.|...|.|||...::...|::||..:...|.|.:.   ::|::         .|.:   |..
Mouse   724 QSVPLDACTKEEARWTIQRCSGLITLHYKVNHEGYRKL---LKEME---------DGLI---TSG 773

  Fly   859 RSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNA---SDDEWWQARRVLGDNEDEQIGIVPS 920
            .|.|:|    .:.|....|.:..:..|..|::||.:.   ...||..||.....::|...|.:||
Mouse   774 DSFYIR----LNLNISSQLDACSMSLKCDDVVHVLDTMYQDRHEWLCARVDPFTDQDLDTGTIPS 834

  Fly   921 KRRWERKMRARDRSVKFQGH-----------AAANNNLDKQ---STLDRK------KKNFTFSRK 965
            ..|.::.:..:.:.:..:|:           .:..|.|..:   ||.|.:      :.:|.|.:.
Mouse   835 YSRAQQLLLVKLQRLVHRGNREEADSAHHTLRSLRNTLQPEEMLSTSDPRVSPRLSRASFFFGQL 899

  Fly   966 FPFMKSRDEK 975
            ..|:...:.|
Mouse   900 LQFVSRSENK 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	14/77 (18%)
		PDZ	454..540	CDD:214570	23/122 (19%)
		PDZ_signaling	566..655	CDD:238492	10/89 (11%)
		PDZ_signaling	742..820	CDD:238492	20/87 (23%)
		SH3_DLG-like	862..922	CDD:212795	16/62 (26%)
Card11	NP_780571.2	CARD_CARD11_CARMA1	22..107	CDD:260070
		Linker. /evidence=ECO:0000250\|UniProtKB:Q9BXL7	111..128
		BAR	<141..>257	CDD:299863	24/86 (28%)
		SPATA1_C	302..437	CDD:292371	29/141 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..496		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..573		9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..626		5/43 (12%)
		PDZ_signaling	680..752	CDD:238492	19/73 (26%)
		SH3	777..839	CDD:302595	17/65 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810