Protein Alignment dlg1 and Card10

DIOPT Version :10

• Sequence 1: NP_001162718.1
• Gene: dlg1 / 32083
• FlyBaseID: FBgn0001624
• Length: 1030
• Species: Drosophila melanogaster
• Sequence 2: XP_036014949.1
• Gene: Card10 / 105844
• MGIID: 2146012
• Length: 1144
• Species: Mus musculus
• Alignment Length: 1060
• Identity: 196/1060 - (18%)
• Similarity: 332/1060 - (31%)
• Gaps: 392/1060 - (36%)

  Fly   119 EPDPEPPKCPTSLRDSVRESVECFYSAQDLLEYGHMLSSTS---MVRTPDVESG----YFEKSES 176
            :|:...|....|.|.|.....:...||:.  |.|.....|:   ..|||....|    ....:..
Mouse    16 DPEGTAPSRLRSRRPSTEPGAQGSCSARG--ECGEDTGGTAAWGRERTPTGRPGGRGRDLSGTRE 78

  Fly   177 DASRDEWE-GPSSSSSGAARCRLLSGISG------LSVSSSSRHSAEGLRMELSRFRTMIETLER 234
            .|.|..|: |.:...|...|.|....::.      ||.:.|...:.:|
Mouse    79 GAGRAAWDPGKTEPDSAGTRGRRPGAVTAAPCPPCLSPAGSEDAAMQG----------------- 126

  Fly   235 ESLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSER---GFWSTIFG----------- 285
                                    |:...:|..|:|:..|||.   ..|..|.|
Mouse   127 ------------------------RADAGEADEEAGAGSGSEAEEDALWERIEGVRHRLTRALNP 167

  Fly   286 --------QAGLAISQDEEERIADIQ---KAHRALELLEDYHARLSEPQDRALRIAIERVIRIFK 339
                    |..:...|||||.::..:   :|:|...|::                    ::|...
Mouse   168 AKLTPYLRQCRVLDEQDEEEVLSTYRFPCRANRTGRLID--------------------ILRCRG 212

  Fly   340 SRLFQALLDIQEFY---ELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTEN 401
            .|.|:|.|:..|||   ..|||...:..|       :.:...:::|     .:.....:.::...
Mouse   213 KRGFEAFLEALEFYYPEHFTLLTGQEPAQ-------RCSMILDEEG-----PEGLTQFLMTEVRR 265

  Fly   402 AKEPTVEQQQKQQQAQQR-----SSRSPQQQNPQQQQGSKSRSGSQTVNGD-DSWLYEDIQLERG 460
            .:|....|..::||.|.|     ..|:..:|..::||.::.|  .|.:..| ::...|.::|:..
Mouse   266 LREARKSQLHREQQLQARGRALEEERAGLEQRLREQQQAQER--CQRLREDWEAGSLELLRLKDE 328

  Fly   461 NSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDA 525
            |..:...:|..::..                           |..::...|:.:       |||.
Mouse   329 NYMIAMRLAQLSEEK---------------------------NSAVLRSRDLQL-------AVDQ 359

  Fly   526 LKKAGNVVKLH-----VKRKRGTATTPAAGSAAGDARDSAASGPKVI------------EIDLVK 573
            ||.  .|.:|.     ::|.||    |..|:   :.::....|..::            .:..::
Mouse   360 LKL--KVSRLEEECALLRRARG----PPPGA---EEKEREPDGADLLSELRAENQRLTASLQELQ 415

  Fly   574 GGKGLGFSIAGGIGNQHIPGDNGIYVTKLM--DGGAAQVDGRLSIGDKLIAVRTNGS-------- 628
            .|.....|..|..|::.|       :..::  |...|| |.|..:..||.||:  |.
Mouse   416 EGLQQEMSRPGAAGSERI-------LLDILEHDWREAQ-DSRQELCQKLHAVQ--GELQWAEELR 470

  Fly   629 EKNLENV-----------------THELA--VATLKSI----------TDKVTL-----IIGKTQ 659
            :|.|:.:                 .|.:|  :|.|:.|          .|::.|     :|.|.|
Mouse   471 DKYLQEMEDLRLKHRTLLKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQ 535

  Fly   660 H--------------LTTSASGGG-------------GG--------------GLSSGQQLSQSQ 683
            :              |||..|..|             ||              .|||...||:..
Mouse   536 YRKQVRGLEAERDELLTTVTSLEGTKAMLEAQLQRTQGGSCLKACASSHSLCSNLSSTWSLSEFP 600

  Fly   684 SQL----ATSQS-QSQVHQQQHAT---------------PMVNS-------QSTEPGSRYAS--T 719
            |.|    ||.:: .|:.|..:.||               |...|       :..||..|..|  :
Mouse   601 SPLGGPEATGEAGGSEPHTSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPEPPKRSFSSMS 665

  Fly   720 NVLAAV-----PPGTPRAVSTEDITREPRTITIQKGPQGL-------------------GFNIVG 760
            ::..:|     .||...:.|::.:....:       |:||                   |::...
Mouse   666 DITGSVTLKPWSPGLSSSSSSDSVWPLGK-------PEGLLARGCGLDFLNRSLAIRVSGWSPPA 723

  Fly   761 GEDGQ---------------GIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQAL 810
            |.|.|               |..|..:|: ||....:|.|                  |..|:..
Mouse   724 GLDPQDKSPDSMPGLGDRWSGAVVRRVLS-GPGSARTEQK------------------EPRAEGT 769

  Fly   811 KTSGGVVTLLAQYRPEEYNRFEARIQELKQQA------ALGAGGSGTLLRTTQKRSLYVRALFDY 869
            ...|..:...||.|...:|:.......|..:|      ||.|...|     ......|:||.|..
Mouse   770 GLEGAGLEAEAQQRTLPWNQSSTLPFLLDSKACHSFHEALDAWAKG-----PGAEPFYIRANFSL 829

  Fly   870 DPNRDDGLPSRGLPFKHGDILHVTNASD---DEWWQARRVLGDNEDEQIGIVPSKRRWERKMRAR 931
             |.|.|   ...|..|..:||.:.:.:.   .||:..|.......|...|.||:.:|.::.:..:
Mouse   830 -PERSD---PHALCVKAQEILRLVDPAHKRRQEWFCTRVDTLTLRDLDRGTVPNYQRAQQLLEVQ 890

  Fly   932 DRSVKFQGHAAANNNLDKQS 951
            ::.:....|.:..:||.|::
Mouse   891 EKYLISSRHRSPRSNLKKRA 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..361	CDD:462665	14/63 (22%)
		PDZ1_Dlg1-2-4-like	452..540	CDD:467206	13/92 (14%)
		PDZ2_Dlg1-2-4-like	568..656	CDD:467207	24/131 (18%)
		PDZ3_Dlg1-2-4-like	741..831	CDD:467257	21/123 (17%)
		SH3_DLG-like	862..922	CDD:212795	18/62 (29%)
Card10	XP_036014949.1	CARD_CARD10_CARMA3	150..235	CDD:260069	22/104 (21%)
		Smc	<262..>573	CDD:440809	64/365 (18%)
		SH3	822..884	CDD:473055	19/65 (29%)