DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and dlg3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_004916882.1	Gene:	dlg3 / 100380042	XenbaseID:	XB-GENE-977252	Length:	869	Species:	Xenopus tropicalis

Alignment Length:	714	Identity:	320/714 - (44%)
Similarity:	434/714 - (60%)	Gaps:	104/714 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 RALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTL-------LDDSKSI 364
            |||.||..|.|.|..|:.:.||.::::|:.:.:|.||||||||||.||:.|       .:.|:..
Frog     9 RALRLLYSYQAELGTPEQQQLRTSLQQVLCMLRSDLFQALLDIQECYEVMLHCTPSAATEHSQME 73

  Fly   365 QQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNP 429
            ..|:.::||.....:..||.....:.|.:|:.:.|...::..:...........::..:|...|.
Frog    74 PYKSQQSLQDTENSQTKGQMTSGLEIQCVRVMARTTEQRKSALTLLSPLHTILPKAGAAPLLVNT 138

  Fly   430 QQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAA 494
            .......|.:||.|:     :.||:|.|||||||||||||||.||||:..|..|:|||:|.||||
Frog   139 DCLDPGSSVNGSDTL-----YKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAA 198

  Fly   495 AADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDS 559
            |.|||||::|.::.||||.|.:|.|:.||:|||:||.||:|.|:|::....|
Frog   199 AMDGRLSVSDCVLRVNDVDVTEVVHSKAVEALKEAGPVVRLLVRRRQSPPET------------- 250

  Fly   560 AASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVR 624
                  ::|::|:||.||||||||||||||||||||.||:||:::|||||.||||.|||:|:||
Frog   251 ------IVEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV- 308

  Fly   625 TNGSEKNLENVTHELAVATLKSITDKVTLIIGK---------------------TQHLTTSASGG 668
               :..||::|.||.|||.||:.:|.|.|.:.|                     ..|::.:::.|
Frog   309 ---NNTNLQDVRHEEAVAALKNTSDMVYLKVAKPGPVHLNEIYAPPDYASTFTVDNHISHNSTLG 370

  Fly   669 GGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAV 733
                           :.|::.:|:|     .:..|.|......|..|:               .:
Frog   371 ---------------AYLSSMESKS-----PYPPPQVTPSRFSPVPRH---------------ML 400

  Fly   734 STEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNL 798
            ..||.|||||.|.:.||..||||||||||||:||:||||||||||||..||:|||::||||.|||
Frog   401 GEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNL 465

  Fly   799 THATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQA--ALGAGGSGTLLRTTQKRSL 861
            ..||||:||.|||.:|..||::||||||||:|||::|.:|::|.  :..:.|||: |||::||||
Frog   466 RSATHEQAAAALKRAGQTVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGS-LRTSEKRSL 529

  Fly   862 YVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWER 926
            |||||||||.:||..|||:||.|.:||||||.|||||||||||.|....|.||||::|||:|.|:
Frog   530 YVRALFDYDRSRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEK 594

  Fly   927 KMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKN-------EDGSDQE 983
            |.|||.::|||.|.:..::|   :|...::||:|..||||||.||..:.|       .:.||.|
Frog   595 KERARLKTVKFHGRSGIDSN---RSIKSKRKKSFRLSRKFPFYKSLVQDNSTAQAVTSNTSDSE 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	26/58 (45%)
		PDZ	454..540	CDD:214570	55/85 (65%)
		PDZ_signaling	566..655	CDD:238492	56/88 (64%)
		PDZ_signaling	742..820	CDD:238492	55/77 (71%)
		SH3_DLG-like	862..922	CDD:212795	42/59 (71%)
dlg3	XP_004916882.1	L27_1	4..59	CDD:370268	25/49 (51%)
		MAGUK_N_PEST	73..157	CDD:371162	14/88 (16%)
		PDZ_signaling	158..242	CDD:238492	54/83 (65%)
		PDZ_signaling	251..337	CDD:238492	56/89 (63%)
		PDZ_assoc	338..410	CDD:371157	15/106 (14%)
		PDZ	408..492	CDD:214570	59/83 (71%)
		SH3_DLG3	527..593	CDD:212962	47/65 (72%)
		Guanylate_kin	678..855	CDD:366206
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5573
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	922	1.000	Inparanoid score	I358
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm47450
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060