DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and magi3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_012811019.1	Gene:	magi3 / 100036692	XenbaseID:	XB-GENE-981179	Length:	1595	Species:	Xenopus tropicalis

Alignment Length:	996	Identity:	207/996 - (20%)
Similarity:	365/996 - (36%)	Gaps:	276/996 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTDSEREKSSDPNEGLLSSDDKTFHDDDEPAEDSSPADDEEEPEEEECLLPQKKAQIRCDQDQPP 68
            ||:::|::::.     :|...:|         |||..::|:| ||.|.:.....:....|:.:|.
Frog   211 DTETQRKRTTS-----VSKMQRT---------DSSLPEEEDE-EEREAVNGSSGSTDHRDRQEPS 260

  Fly    69 LVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDMD------GDSQLE-----------------VM 110
            ......||         .:.||        |.||      .|..||                 .:
Frog   261 EWGKTVPS---------YNQTN--------SSMDFRNYLTRDENLEPLPKNWEMAYTEAGMIYFI 308

  Fly   111 EHQMETVTEPDP---EPPKCPTSLRDSVRESVECFYSAQDL--LEYG-----HMLSSTSMVRTPD 165
            :|..:|.|..||   :..|.|....|.     |..|..:.:  .:||     |:...|.
Frog   309 DHNTKTTTWLDPRLCKKAKAPEDCEDG-----ELPYGWEKIEDPQYGTYYVDHINQKTQ------ 362

  Fly   166 VESGYFEKSESDASRDEWEGPSSSS-------SGAARCRLLSGISGLSVSSSSRHSAEGLRMELS 223
                 |:....:|.|.:...|:.|.       ..:...|..|.:.|..:.:|.:.||.|...
Frog   363 -----FDNPVLEAKRKKQLNPAPSEGTVHQEPENSQFTRDPSQLKGALLHTSLKKSAMGFGF--- 419

  Fly   224 RFRTMIETLERESLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWSTIFGQA- 287
               |:|      ..::....||:|...|..|.      .||.....|.......|  :.:.|..
Frog   420 ---TII------GGDRPDEFLQVKNVLKDGPA------AQDGKIAPGDVIVDING--TCVLGHTH 467

  Fly   288 ----------------------GLAISQDEEERIADIQKAHRAL---ELLEDYHARLSEPQDRAL 327
                                  |..:.:|.::.:|||......:   ::|......:...:.::.
Frog   468 AEVVQMFQLIPINQYVNMTLCRGYPLPEDSDDPVADIVNTVPPIINGQMLTQGDINMGSQELKSG 532

  Fly   328 RIAIER----VIRIFKSRLFQALLDIQ--------------EFYELTLLDDSKSIQQKTAET--- 371
            .|.:::    .:.:...||....||||              |...:.||...|......|::
Frog   533 VIDLDQRGKPGLMVVNGRLNGPSLDIQDQRTSMASSGNSLPELVTIPLLKGPKGFGFAIADSPMG 597

  Fly   372 ----LQIATKW---EKDGQAVKIADNQRMR------------------------IESDTENAKEP 405
                :.:.::|   .:.|..:|...:|.::                        :.....:..:.
Frog   598 QKVKMILDSQWCPGLQKGDVIKEICHQNVQNLTHIQVVEVLKQFPVGAEVPLLILRGGPPSPSKV 662

  Fly   406 TVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYE----------------D 454
            |..:..||:......:.:|.:..||......:.:.|.:...|.|.:|:                |
Frog   663 TKVKSDKQELMGSIEAIAPGEPLPQPLPFPPNLARSCSPKLDPSEVYKKSKNIFEDKPPNTKDLD 727

  Fly   455 IQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPH 519
            :.|.:..||.||.:.||.     |.|.:|||..:|..|||..||||...|.::.::.|.|....|
Frog   728 VFLRKQESGFGFRVLGGD-----GPDQAIYIGAIIPLGAAEKDGRLRAADELICIDGVPVKGKSH 787

  Fly   520 ASAVDALKKA---GNVVKLHVKR-----------KRGTATTPAAGSAAGDARDSAASGPKV--IE 568
            ...:|.:..|   |:|: |.|:|           :....|.||...:....|...::.||:  ..
Frog   788 KQVLDLMTNAARNGHVL-LTVRRQIYYTDKQQEEEELQHTPPAHNGSPRLNRIEVSAIPKLPAEA 851

  Fly   569 IDLV---KGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEK 630
            .|::   |..:|.||.|... .|:..||.....:.::::|..|....:|.:||::.||  ||  :
Frog   852 YDVILQRKDNEGFGFVILTS-KNKPPPGVIPHKIGRVIEGSPADRCRKLKVGDRISAV--NG--Q 911

  Fly   631 NLENVTHELAVATLKSITDKVTL-IIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQ 694
            ::..::|:..|..:|...:.||| :|.:.:|          .|..||            |.|..|
Frog   912 SIVELSHDNIVQLIKDAGNTVTLTVIAEEEH----------RGPPSG------------SNSARQ 954

  Fly   695 VHQQQHATPMVNSQSTEPGS--RYASTNVLA----AVPPGTPRAVSTEDITREPRTITIQKGPQG 753
            ....|| .||..:|.|. |:  ||:.::..|    |:|.|:.:|   :.:...|  :.:::||:|
Frog   955 SPAPQH-RPMGQTQPTY-GTLDRYSWSDHKADCGPALPAGSWQA---QSVGCYP--VELERGPRG 1012

  Fly   754 LGFNIVGGED-GQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVV 817
            .||::.||:: ..|:::..:...|||.....:..|||::.:||......||..|.:.::..|..|
Frog  1013 FGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINNEPTQGITHTRAIELIQAGGSKV 1077

  Fly   818 TLLAQYRP-----EEYNRFEA 833
            .||  .||     .:||..::
Frog  1078 LLL--LRPGTGLIPDYNELDS 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	10/76 (13%)
		PDZ	454..540	CDD:214570	32/99 (32%)
		PDZ_signaling	566..655	CDD:238492	24/94 (26%)
		PDZ_signaling	742..820	CDD:238492	22/78 (28%)
		SH3_DLG-like	862..922	CDD:212795
magi3	XP_012811019.1	PDZ_signaling	31..97	CDD:238492
		NK	119..>193	CDD:388413
		WW	290..322	CDD:197736	5/31 (16%)
		WW	337..368	CDD:197736	6/41 (15%)
		PDZ	410..490	CDD:214570	15/99 (15%)
		PDZ	574..655	CDD:214570	9/80 (11%)
		PDZ_signaling	727..808	CDD:238492	30/86 (35%)
		PDZ_signaling	852..937	CDD:238492	24/89 (27%)
		PDZ_signaling	1004..1082	CDD:238492	23/79 (29%)
		PTZ00121	<1202..1571	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910