DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Jak1

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_445918.1	Gene:	Jak1 / 84598	RGDID:	69056	Length:	1153	Species:	Rattus norvegicus

Alignment Length:	1254	Identity:	302/1254 - (24%)
Similarity:	495/1254 - (39%)	Gaps:	318/1254 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 TGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTS--RRPSPLVRLDLTWCLPGERLN 117
            :||:       ..||:|....::..|:|:...|:.:.:.||.  ..|:.::.:|       ::::
  Rat    52 SGEY-------TAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVD-------DKMS 102

  Fly   118 CQLVYCFRMRF------------------------------RVPELDSQLELIDGRSHKFLYRQM 152
            .:|.|  ||||                              :|||   ...|:|..|.::|:.|.
  Rat   103 LRLHY--RMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPE---ATPLLDASSLEYLFAQG 162

  Fly   153 RYDMRTEQIPEIRYPE-----H--KDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKL--------Y 202
            :||: .:.:..||.|:     |  :::..|:||:.:         ...||....:|        |
  Rat   163 QYDL-IKCLAPIRDPKTEQDGHDIENECLGMAVLAI---------SHYAMMKKMQLPELPKDISY 217

  Fly   203 KLYLPPSL---WRAHSFFVGSKIREVFRS-LKA--------NSLSVERLKWHYVHQVSHLAPTYM 255
            |.|:|.:|   .|..:.....:|..||:. ||.        :|:|...||..|:..:..|...|.
  Rat   218 KRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYG 282

  Fly   256 TEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRR 320
            .|.|                         .||.|..| |.|.||...:|       .||......
  Rat   283 AEIF-------------------------ETSMLLIS-SENELSRCHSN-------DSGNVLYEV 314

  Fly   321 STSGGIDVYVR----VFPHDSLEPGLKVARV----------TSEATLKWILVGAVEGIFMISKIN 371
            ..:|.:.:..|    |.|.:..:..||..::          .::...:|      .......:|.
  Rat   315 MVTGNLGIQWRQKPNVLPVEKEKNKLKRKKLDYNKHKKEDDRNKLREEW------NSFSYFPEIT 373

  Fly   372 DTSVRLEIVGL----PKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSL 432
            ...::..:|.:    .|..|::..:.:|..||:|.:..|.||::.....||.....|.:......
  Rat   374 HIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQN 438

  Fly   433 HCHGPIGGAYSLMKLHENGDKCGSYIVR-ECDREYNIYYIDINTKIMAKKTD----QERCKTETF 492
            .|||||...|::.||.:.|.:.|.|::| .|....||    :.|....:|::    |::.|  .|
  Rat   439 GCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNI----LMTVSCFEKSEVLGNQKQFK--NF 497

  Fly   493 RIVRKDSQWKLSYNNGEH------VLNSLHEVAHIIQADSPDRYRIPASKYDKPPLLLLLLPKNL 551
            :|..:..::.| :.:.:|      ::|.|.:  .|::.|:.. :.:......||..:..||....
  Rat   498 QIEVQKGRYSL-HGSVDHFPSLRDLMNHLKK--QILRTDNIS-FVLKRCCQPKPREISNLLVATK 558

  Fly   552 KAKK-----TDLQLS----------EAELQRRNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDW 601
            ||::     :..|||          :.|...|..:.......|..|.|...::::
  Rat   559 KAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEE---------- 613

  Fly   602 IQQSPVKDVSVTMKMLKSDGN--FMEFFRLAQTWSLIQSPQFLKLYGLTLAD-PYTMVMEYSRYG 663
                  |.:.|.:|:|.....  .:.||..|.....:.....:.|||:.:.| ...||.|:...|
  Rat   614 ------KKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGG 672

  Fly   664 PLNKFLHSMPN-VTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTK----YDPNSYVLDA 723
            ||:.|:|...: :|......:...|...:.||||..::|..:...||.:.:    .|...::
  Rat   673 PLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFI--- 734

  Fly   724 KISDPGYP-----RPYRESDSPWIP---VKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLS 780
            |:||||.|     |.......|||.   |:..:||..|     |..|:|.||::||   |.....
  Rat   735 KLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVA-----ADKWSFGTTLWEI---CYNGEI 791

  Fly   781 TLRQEQLLRQ---------------KNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHD 830
            .|:.:.|:.:               |.|...:.:.::.|....|.|..||             .|
  Rat   792 PLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIM-------------RD 843

  Fly   831 IFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNME 895
            | ::|.....:|:....|..|:      |.|..::.   ||...|.
  Rat   844 I-NKLEEQNPDIVSEKQPITEV------DPTHFEKR---FLKRIRD------------------- 879

  Fly   896 NMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVS---TDFHREIGIMRTLSHPNIVKFKY 957
              :|.||:|.|.....: .:.|...||||:|.|......   .|..:||.|:|.|.|.||||:
  Rat   880 --LGEGHFGKVELCRYD-PEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY-- 939

  Fly   958 WAEKSHC---------IIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHR 1013
               |..|         :|||:|.|||...||......:|..:.:.:|:.|..||.||.....:||
  Rat   940 ---KGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHR 1001

  Fly  1014 DLAARNILVDHNGDGDCVKISDFGLAQFANSD-GYYYAKSKRDIPIRWYSPEAISTCRFSSYSDV 1077
            ||||||:||:....   |||.||||.:...:| .||..|..||.|:.||:||.:..|:|...|||
  Rat  1002 DLAARNVLVESEHQ---VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDV 1063

  Fly  1078 WSYGVTLFEMFSRGEEPNLVPI------------QTSQEDFLNRLQSGERLNRPASCPDFIYDLM 1130
            ||:||||.|:.:..:. :..|:            |.:....:|.|:.|:||:.|.:|||.:|.||
  Rat  1064 WSFGVTLHELLTYCDS-DFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLM 1127

  Fly  1131 QLCWHATPRSRPSFATIVD 1149
            :.||...|.:|.:|..:::
  Rat  1128 RKCWEFQPSNRTTFQNLIE 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604	57/262 (22%)
		SH2_Jak_family	420..516	CDD:198177	25/106 (24%)
		PTK_Jak_rpt1	584..836	CDD:270633	63/282 (22%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	100/289 (35%)
		TyrKc	894..1151	CDD:197581	100/281 (36%)
Jak1	NP_445918.1	B41	37..286	CDD:214604	57/262 (22%)
		FERM_C_JAK1	282..426	CDD:275412	33/182 (18%)
		SH2_Jak1	426..526	CDD:198241	25/106 (24%)
		PTK_Jak1_rpt1	582..845	CDD:270662	67/303 (22%)
		Pkinase_Tyr	582..844	CDD:285015	65/301 (22%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	103/312 (33%)
		Pkinase_Tyr	874..1146	CDD:285015	102/302 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3138
OMA	1	1.010	-	-		QHG47769
OrthoDB	1	1.010	-	-		D38412at33208
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		otm44657
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980