DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Tec

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_445884.1	Gene:	Tec / 84492	RGDID:	620973	Length:	629	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	132/495 - (26%)
Similarity:	207/495 - (41%)	Gaps:	87/495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 LVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQ 751
            |.||..|               :.:.|.|.:.:....|....||           ||..|....:
  Rat   198 LERGQEY---------------IILEKNDTHWWRARDKYGSEGY-----------IPSNYVTGKK 236

  Fly   752 AAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMD 816
            :...||           ||.:.|   :.:..:.|||||.::.:|..  |:.....|.....::..
  Rat   237 SNNLDQ-----------YEWYCR---NTNRSKAEQLLRTEDKEGGF--MVRDSSQPGLYTVSLYT 285

  Fly   817 GWSDDETKRFSHHDIFSRLNTIKAEILPN---YMPPPEIAT----NGTGDETVIDRSDIPFLPFP 874
            .:..:.:..|.|:.|.....:.|...|..   :...|||..    |..|   ::.|     |.:|
  Rat   286 KFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAG---LVTR-----LRYP 342

  Fly   875 RSNMLMVIPLT----------SECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLN 929
            .|......|.|          :...:.:..|  :|.|.:|.|..|      |.:.:.:||||.:.
  Rat   343 VSTKGKNAPTTAGFSYDKWEINPSELTFMRE--LGSGLFGVVRLG------KWRAQYKVAIKAIR 399

  Fly   930 T-MQVSTDFHREIGIMRTLSHPNIVKFKYWA---EKSHCIIMEYLQSGSFDIYLRFTAPNLNNPR 990
            . .....||..|..:|..|:||.:|:. |..   :|...|:.|:::.|....:||....:.:...
  Rat   400 EGAMCEEDFIEEAKVMMKLTHPKLVQL-YGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDV 463

  Fly   991 LVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRD 1055
            |:|...|:..||:||.....|||||||||.||:..|   .||:||||:|::. .|..|.:.|...
  Rat   464 LLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG---VVKVSDFGMARYV-LDDQYTSSSGAK 524

  Fly  1056 IPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPA 1120
            .|::|..||..:..||||.|||||:||.::|:|:.|..|.   .:.:..:.:..:..|.||.||.
  Rat   525 FPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPF---EKNTNYEVVTMVTRGHRLPRPK 586

  Fly  1121 SCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVT 1160
            ....::|::|..||...|..||||..::..|...|..:.|
  Rat   587 LASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEET 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	28/148 (19%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	89/272 (33%)
		TyrKc	894..1151	CDD:197581	88/260 (34%)
Tec	NP_445884.1	PH_Btk	7..148	CDD:269944
		SH3_Tec	181..235	CDD:212838	12/62 (19%)
		SH2_Tec_Itk	238..345	CDD:198259	26/130 (20%)
		PTKc_Tec_Rlk	363..622	CDD:270685	89/274 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900