DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Lyn

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_110484.1	Gene:	Lyn / 81515	RGDID:	621017	Length:	512	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	122/442 - (27%)
Similarity:	189/442 - (42%)	Gaps:	87/442 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 WIPVKYYRNLQAAKTDQF-----------AQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLD 794
            :||..|...:...:|:::           .||.|...:......|..|   ||:....|..::.|
  Rat   112 FIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESE---TLKGSFSLSVRDYD 173

  Fly   795 ---GNILK-----MLDQD---ICPAPIFETIMDGWSDDETKRFSHHD-----IFSRLNTIKAEIL 843
               |:::|     .||..   |.|...|..|.|        ...|:.     :..||.  ||.|.
  Rat   174 PMHGDVIKHYKIRSLDNGGYYISPRITFPCISD--------MIKHYQKQSDGLCRRLE--KACIS 228

  Fly   844 PNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYK 908
            |....|                .|......||.::.:|              ..:|.|.:|.|:.
  Rat   229 PKPQKP----------------WDKDAWEIPRESIKLV--------------KKLGAGQFGEVWM 263

  Fly   909 GHLEFNDKDQPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVKFKYWAEKSH--CIIMEYL 970
            |:...:.|      ||:|.|....:|.. |..|..:|:||.|..:|:......|..  .||.|::
  Rat   264 GYYNNSTK------VAVKTLKPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFM 322

  Fly   971 QSGSFDIYLRF-TAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKIS 1034
            ..||...:|:. ....:..|:|:.|:..||.||.|:.....|||||.|.|:||   .:....||:
  Rat   323 AKGSLLDFLKSDEGSKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLV---SESLMCKIA 384

  Fly  1035 DFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPI 1099
            |||||:.. .|..|.|:.....||:|.:||||:...|:..|||||:|:.|:|:.:.|:.|  .|.
  Rat   385 DFGLARVI-EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIP--YPG 446

  Fly  1100 QTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII 1151
            :|: .|.:..|..|.|:.|..:|||.:||:|::||..:...||:|..:..::
  Rat   447 RTN-ADVMTALSQGYRMPRMENCPDELYDIMKMCWKESAEERPTFDYLQSVL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	24/121 (20%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	88/270 (33%)
		TyrKc	894..1151	CDD:197581	88/260 (34%)
Lyn	NP_110484.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		SH3_Lyn	67..122	CDD:212937	3/9 (33%)
		SH2_Src_Lyn	125..225	CDD:198227	22/112 (20%)
		PTKc_Lyn	239..510	CDD:270657	91/286 (32%)
		Pkinase_Tyr	247..497	CDD:285015	89/276 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810