DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and itk

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_571179.1	Gene:	itk / 798906	ZFINID:	ZDB-GENE-990415-261	Length:	616	Species:	Danio rerio

Alignment Length:	506	Identity:	142/506 - (28%)
Similarity:	222/506 - (43%)	Gaps:	104/506 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 CSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSP----------WIPVKYYRNLQAAKTDQF-- 758
            ||..|     ||.    ||...| .|.|.|.|..|          :|| |.:.:|...|.:::
Zfish   142 CSEYY-----PNG----AKPLPP-TPDPSRRSSEPEERIVVALRNFIP-KEHTDLPLQKDEEYFI 195

  Fly   759 -----AQLWAF---------ATTIY---------EIFSRCKEDLSTLRQEQLLRQKNLDGNIL-- 798
                 ...|..         ...||         |.|....:|::....|.||.|:|.||..:
Zfish   196 VDCSEPNWWTVKDKDGNVGSVPCIYVTEKLSNNIEKFEWYNKDINRTEAEDLLMQENKDGGFMVR 260

  Fly   799 KMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAE-------ILPNYMPP--PEIAT 854
            ......:....|| |.:.|.:.::..:..|:.|     .:::|       :...|:.|  ||:..
Zfish   261 NSKHAGVYTVSIF-TRVSGSNGEKCPQVKHYQI-----KVQSEGEKVLYYLAEKYLFPTIPELIR 319

  Fly   855 ----NGTGDETVIDR------SDIPFLPFPRSNMLMVIPLTSECRVIY----NMENMIGRGHYGT 905
                |..|   :|.|      .::|       |...:..|:|:...|:    .:...:|.|.:|.
Zfish   320 YHQHNPAG---LITRLRHCVSRNVP-------NSARIKELSSDKWEIHPDEVKLSVELGSGQFGL 374

  Fly   906 VYKGHLEFNDKDQPREQVAIKMLNTMQVS-TDFHREIGIMRTLSHPNIVK-FKYWAEKSHC-IIM 967
            |:||  .:.|:     :||:|.:....:| .:|..|..:|..|||..:|: :....::|.. ::.
Zfish   375 VWKG--SWQDR-----EVAVKTVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVF 432

  Fly   968 EYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVK 1032
            |::::|....:||.....|:...|:...||::.||.||.....|||||||||.||..|   ..||
Zfish   433 EFMENGCLTEFLRAKKGKLSQKALLEMCLDVSEGMAYLESSNFIHRDLAARNCLVSEN---SVVK 494

  Fly  1033 ISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLV 1097
            |:|||:.:|...|.|..:...: .|:||.|||.|...::||.|||||:||.::|::|.|..|.
Zfish   495 IADFGMTRFVLDDQYTSSHGSK-FPVRWSSPEVIKFGKYSSKSDVWSFGVFMWEVYSEGRTPY-- 556

  Fly  1098 PIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIV 1148
             ...|..:.:..|.:|.||.:|..||..:|:|||..|...|..|||||.::
Zfish   557 -DNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKEKPEDRPSFALLL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	37/166 (22%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	93/270 (34%)
		TyrKc	894..1151	CDD:197581	91/258 (35%)
itk	NP_571179.1	PH	5..110	CDD:278594
		PH_Btk	7..147	CDD:269944	3/9 (33%)
		SH3_Tec_like	170..223	CDD:212702	8/53 (15%)
		SH2_Tec_family	227..338	CDD:198188	25/119 (21%)
		PKc_like	356..610	CDD:304357	92/265 (35%)
		Pkinase_Tyr	361..609	CDD:285015	91/260 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810