DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and TEC

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_003206.2	Gene:	TEC / 7006	HGNCID:	11719	Length:	631	Species:	Homo sapiens

Alignment Length:	498	Identity:	132/498 - (26%)
Similarity:	210/498 - (42%)	Gaps:	93/498 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 LVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQ 751
            |.||..|               |.:.|.|.:.:....|..:.||           ||..|....:
Human   200 LERGQEY---------------LILEKNDVHWWRARDKYGNEGY-----------IPSNYVTGKK 238

  Fly   752 AAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMD 816
            :...||           ||.:.|   :::..:.|||||.::.:|..  |:.....|.....::..
Human   239 SNNLDQ-----------YEWYCR---NMNRSKAEQLLRSEDKEGGF--MVRDSSQPGLYTVSLYT 287

  Fly   817 GWSDDETKRFSHHDIFSRLNTIKAEILPN---YMPPPEIAT----NGTGDETVIDRSDIPFLPFP 874
            .:..:.:..|.|:.|.....:.|...|..   :...|||..    |..|   ::.|     |.:|
Human   288 KFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAG---LVTR-----LRYP 344

  Fly   875 RSNMLMVIPLTSECRVIYNMENM------------IGRGHYGTVYKGHLEFNDKDQPREQVAIKM 927
            .|......|.|:.    ::.|..            :|.|.:|.|..|      |.:.:.:||||.
Human   345 VSVKGKNAPTTAG----FSYEKWEINPSELTFMRELGSGLFGVVRLG------KWRAQYKVAIKA 399

  Fly   928 LNT-MQVSTDFHREIGIMRTLSHPNIVKFKYWA---EKSHCIIMEYLQSGSFDIYLRFTAPNLNN 988
            :.. .....||..|..:|..|:||.:|:. |..   :|...|:.|:::.|....:||....:.:.
Human   400 IREGAMCEEDFIEEAKVMMKLTHPKLVQL-YGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR 463

  Fly   989 PRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSK 1053
            ..|:|...|:..||:||.....|||||||||.||...|   .||:||||:|::. .|..|.:.|.
Human   464 DVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAG---VVKVSDFGMARYV-LDDQYTSSSG 524

  Fly  1054 RDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQT-SQEDFLNRLQSGERLN 1117
            ...|::|..||..:..||||.|||||:||.::|:|:.|.    :|.:. :..:.:..:..|.||.
Human   525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGR----MPFEKYTNYEVVTMVTRGHRLY 585

  Fly  1118 RPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVT 1160
            :|....:::|::|..||...|..||||..::..|...|..:.|
Human   586 QPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEET 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	29/148 (20%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	88/285 (31%)
		TyrKc	894..1151	CDD:197581	87/273 (32%)
TEC	NP_003206.2	PH_Btk	7..148	CDD:269944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..178
		SH3_Tec	182..237	CDD:212838	13/62 (21%)
		SH2_Tec_Itk	240..346	CDD:198259	26/129 (20%)
		PTKc_Tec_Rlk	365..624	CDD:270685	87/273 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900