DRSC/TRiP Functional Genomics Resources

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Protein Alignment hop and SRC

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:XP_016883513.1 Gene:SRC / 6714 HGNCID:11283 Length:542 Species:Homo sapiens


Alignment Length:266 Identity:95/266 - (35%)
Similarity:145/266 - (54%) Gaps:20/266 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   894 MENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVK-FK 956
            :|..:|:|.:|.|:.|  .:|.    ..:||||.|....:|.: |.:|..:|:.|.|..:|: :.
Human   278 LEVKLGQGCFGEVWMG--TWNG----TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 336

  Fly   957 YWAEKSHCIIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNI 1020
            ..:|:...|:.||:..||...:|: .|...|..|:||..|..||:||.|:..|..:||||.|.||
Human   337 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 401

  Fly  1021 LVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLF 1085
            ||   |:....|::|||||:.. .|..|.|:.....||:|.:|||....||:..|||||:|:.|.
Human   402 LV---GENLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 462

  Fly  1086 EMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSF----AT 1146
            |:.::|..|  .|...::| .|::::.|.|:..|..||:.::|||..||...|..||:|    |.
Human   463 ELTTKGRVP--YPGMVNRE-VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 524

  Fly  1147 IVDIIT 1152
            :.|..|
Human   525 LEDYFT 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604
SH2_Jak_family 420..516 CDD:198177
PTK_Jak_rpt1 584..836 CDD:270633
PTKc_Jak_rpt2 886..1155 CDD:270634 95/266 (36%)
TyrKc 894..1151 CDD:197581 94/263 (36%)
SRCXP_016883513.1 SH3_Src 88..149 CDD:212941
SH2_Src_Src 153..253 CDD:198228
PTKc_Src 266..542 CDD:270656 95/266 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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