DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and fynb

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001025140.1	Gene:	fynb / 574422	ZFINID:	ZDB-GENE-050706-89	Length:	544	Species:	Danio rerio

Alignment Length:	517	Identity:	134/517 - (25%)
Similarity:	209/517 - (40%)	Gaps:	117/517 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 LYVTKYDPNS--------------YVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQF- 758
            |:|..||..:              .::::...|....|......:.:||..|     .|..|..
Zfish    93 LFVALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNY-----VAPVDSIQ 152

  Fly   759 AQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDET 823
            |:.|.|.       ...::|    .:.|||...|..|..| :.:.:........:|.| |.|.:.
Zfish   153 AEDWYFG-------KLGRKD----AERQLLSTGNPRGTFL-IRESETTKGAFSLSIRD-WDDVKG 204

  Fly   824 KRFSHHDIFSRLN------TIKAE----------------------ILPNYMPPPEIATNGTGDE 860
            ....|:.| .:|:      |.:|:                      ::|.:...|.:.      :
Zfish   205 DHVKHYKI-RKLDSGGYYITTRAQFETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLT------D 262

  Fly   861 TVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAI 925
            ..:...|:  ...||.::.::              ..:|.|.:|.|:.|....|.|      |||
Zfish   263 LSVKTKDV--WEIPRESLQLI--------------KRLGNGQFGEVWMGTWNGNTK------VAI 305

  Fly   926 KMLNTMQVSTD-FHREIGIMRTLSHPNIVK-FKYWAEKSHCIIMEYLQSGSFDIYLR-FTAPNLN 987
            |.|....:|.: |..|..||:.|.|..:|: :...:|:...|:.||:..||...:|: .....|.
Zfish   306 KTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMGKGSLLDFLKDGEGRALK 370

  Fly   988 NPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKS 1052
            .|.||..|..:|.||.|:..|..|||||.:.||||   ||....||:|||||:.. .|..|.|:.
Zfish   371 LPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILV---GDSLVCKIADFGLARLI-EDNEYTARQ 431

  Fly  1053 KRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLN 1117
            ....||:|.:|||....:|:..|||||:|:.|.|:.::|..|  .|...::| .|.:::.|.|:.
Zfish   432 GAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVP--YPGMNNRE-VLEQVERGYRMQ 493

  Fly  1118 RPASCPDFIYDLMQLCWHATPRSRPSF----ATIVDIITREVATKVTHPTDGHQSPPNQPTD 1175
            .|..||..:::||..||......||:|    |.:.|..|   ||:          |..||.|
Zfish   494 CPQDCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFT---ATE----------PQYQPGD 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	27/141 (19%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	93/275 (34%)
		TyrKc	894..1151	CDD:197581	92/263 (35%)
fynb	NP_001025140.1	SH3_Fyn_Yrk	92..147	CDD:212939	9/58 (16%)
		SH2_Src_Fyn_isoform_a_like	152..252	CDD:198281	19/113 (17%)
		PKc_like	268..541	CDD:304357	100/314 (32%)
		Pkinase_Tyr	278..527	CDD:285015	91/275 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810