DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and abl2

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_005166946.1	Gene:	abl2 / 570636	ZFINID:	ZDB-GENE-020809-2	Length:	1182	Species:	Danio rerio

Alignment Length:	369	Identity:	121/369 - (32%)
Similarity:	184/369 - (49%)	Gaps:	56/369 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   833 SRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSN---MLMVIPLTSEC---RVI 891
            ||.:|: ||::.::      :|...|..|.:      ..|.|:.|   :..|.|:..:.   |..
Zfish   241 SRFSTL-AELVHHH------STVADGLVTTL------HYPAPKCNKPTVYGVSPIHDKWEMERTD 292

  Fly   892 YNMENMIGRGHYGTVYKG-HLEFNDKDQPREQVAIKML--NTMQVSTDFHREIGIMRTLSHPNIV 953
            ..|::.:|.|.||.||.| ..::|      ..||:|.|  :||:|. :|.:|..:|:.:.|||:|
Zfish   293 ITMKHKLGGGQYGEVYVGVWKKYN------LTVAVKTLKEDTMEVE-EFLKEASVMKEVKHPNLV 350

  Fly   954 KF--KYWAEKSHCIIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDL 1015
            :.  ....|....|:.||:..|:...||| .....:|...|:..|..|::.|:||.....|||||
Zfish   351 QLLGVCTLEPPFYIVTEYMPHGNLLDYLRECERDQVNAVVLLYMATQISSAMEYLEKKNFIHRDL 415

  Fly  1016 AARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSY 1080
            ||||.||   |:...||::||||::....| .|.|.:....||:|.:||:::...||..||||::
Zfish   416 AARNCLV---GENHVVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAF 476

  Fly  1081 GVTLFEMFSRGEEPNLVP-IQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSF 1144
            ||.|:|:.:.|..|  .| |..||  ..:.|:.|.|:.:|..||..:|:||:.||..:|..||||
Zfish   477 GVLLWEIATYGMSP--YPGIDLSQ--VYDLLEKGYRMEQPEGCPPKVYELMRACWQWSPLDRPSF 537

  Fly  1145 ATIVDI---------ITREVATKVTHPTDGHQS------PPNQP 1173
            |.|...         |:.|||.::.....|.||      .|:.|
Zfish   538 AEIHQAFETMFHDSSISEEVAEELCKTASGGQSGVAHTFGPDMP 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	2/2 (100%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	100/287 (35%)
		TyrKc	894..1151	CDD:197581	98/272 (36%)
abl2	XP_005166946.1	SH3_Abl	116..169	CDD:212784
		SH2_ABL	174..267	CDD:198189	8/38 (21%)
		PTKc_Abl	286..548	CDD:270645	99/276 (36%)
		Pkinase_Tyr	293..544	CDD:285015	98/265 (37%)
		FABD	1057..1182	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910