DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and jak3

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_002663133.4	Gene:	jak3 / 561370	ZFINID:	ZDB-GENE-070725-4	Length:	1103	Species:	Danio rerio

Alignment Length:	1268	Identity:	307/1268 - (24%)
Similarity:	500/1268 - (39%)	Gaps:	304/1268 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSIHTNDGTIRVFNFTTGEFERFHPNM 65
            |.....|..|....|:.:..|..|.||.:.:                  .|:..||       ::
Zfish    10 MKSERAGSQRSSCDSALQVHLYYSPSLNSET------------------TFSIPTG-------HV 49

  Fly    66 LCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCLPGERL----NCQLVYCFRM 126
            ..|.:|....:..||.|:...|:.:...            ||::..|...|    ....|| :|:
Zfish    50 TAESVCVLAAKASGILPVYHNLFALASE------------DLSYWYPPNHLFKSEEPVKVY-YRV 101

  Fly   127 RF-------RVPELDSQLELIDGRSH--------KFLYRQMRYDMRT---EQIPEIRYPEHKDKS 173
            ||       :......:..|..||..        .:::.|.|.|..|   ...|.:..   :.:.
Zfish   102 RFFFSSWFGQESRASYRFSLSKGRIFAVLDYAVIDYVFAQSRSDFVTGCGGISPALSL---QQEC 163

  Fly   174 TGLAVMDMLIDDQEQSEDQQAMRSI--EKLYKLYLPPS-------LWRAHSFFVGSKIREVFRSL 229
            .||||:|:.   :...|..|::..|  ...||..||.:       :.|...:.:...::...:.|
Zfish   164 LGLAVLDLW---RLAKERNQSLAEICNTTSYKSCLPETHRQDIQRMNRLARYQIRKTLKRFLKKL 225

  Fly   230 KANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGS 294
            ...|.....||..|:.::|.|.|.|.:|.|                 |:     |.:..|..|..
Zfish   226 GKCSAGERSLKLKYLMKLSELEPDYGSESF-----------------PL-----HHSGWLEQSEQ 268

  Fly   295 TNTLSTLTTNTNSVALGGSG----KKAKRRSTSGGIDVYVRVFPH--DSLEPGLKVARVTSEATL 353
            ...|        :|.:.|.|    :|..|:......|     ||.  |     :.:.|:..|..
Zfish   269 QRVL--------AVKVSGEGGIQIQKTDRQEWQTFCD-----FPQIID-----ISIKRLCQEQM- 314

  Fly   354 KWILVGAVEG-IFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDL 417
                  .:|| :..:::.:|..:           |.:|||..:..||:|.:..|.||::......
Zfish   315 ------PLEGRVVTLTRQDDQCM-----------EAEFQTLTDALSFVSLVDGYFRLTTDSTHYF 362

  Fly   418 CHSYRTPSLEELSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYID--INTKIMAK 480
            |.....|||.|....:|||||...:::.||.:.|.|.|.:::|...:|::.|::.  |.|.:
Zfish   363 CAEVAPPSLLEDIQNYCHGPITSEFAVHKLKKAGGKNGMFLLRHSPKEFDKYFLTVCIQTPL--- 424

  Fly   481 KTDQERCKTETFRIVRKDSQWKLSYNNGEHVLNSLHEVAHIIQADSPDRYRIPASKYDKPPLLL- 544
            ..|.:.|      ::.|:.::.|:   |.|  ||...:..:|     |.|::........|:.|
Zfish   425 GMDYKDC------LIEKNEKFSLA---GIH--NSFINLKQLI-----DFYQLSTLYVSDIPVTLG 473

  Fly   545 ------------LLLPKNLKAKKTDLQLSEAELQRRNPQIFN----PRTDLQWYPDSISLSDDGM 593
                        :::.:|  :..|::. |...|||..|....    ...||.|   |.||.....
Zfish   474 KCCPPRAKELTNMIIIRN--SSMTEIP-SSPTLQRHKPSHMQFHMIKHEDLIW---SESLGQGSF 532

  Fly   594 MFTMRGDWIQQ--SPVKDVSVTMKMLKSDGN----FMEFFRLAQTWSLIQSPQFLKLYGLTL-AD 651
            ....||..|.|  .......|.:|:|  |.|    :...|..|...|.|.....|.:||::: ..
Zfish   533 THIFRGSKIDQRDGGTHSTEVLLKVL--DANHKNCWESLFEAASLMSQISHRHLLLVYGISVHKS 595

  Fly   652 PYTMVMEYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDP 716
            ...||.|:.::|.|:.:|.....|::...||:...|...:::||:..|.|..|...||.:.:...
Zfish   596 KNIMVQEFVKHGALDLYLKRSMCVSVSWKLDVAKQLACALNFLEEKNIAHGNICAKNLLLVREGD 660

  Fly   717 NSYVLDAKISDPGYPRPYRESD-----SPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCK 776
            :.::   |:||||........|     .||:..:.   |...:.:.....|:|.||::|||:..:
Zfish   661 SPFI---KLSDPGVSMSLLGKDVVLDRIPWVAPEV---LDTLEIELECDKWSFGTTLWEIFNGGE 719

  Fly   777 EDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIK-- 839
            ..|..|                                      |..::...::.||.|.|::
Zfish   720 APLQGL--------------------------------------DLMQKLQFYENFSNLPTLEWT 746

  Fly   840 --AEILPNYMP-PPEIATNG-----------TGDETVIDRSDIPFLPFPRSN----MLMVIPLTS 886
              ||::.:.|. .||:..:.           |.|..::..:|    ..|.||    .|.:.....
Zfish   747 ELAELISHCMQYQPELRPSCRSIIRQLNSLITSDYEILHATD----TLPESNGFWKKLNIFKKQQ 807

  Fly   887 E-------CRVIYNMENMIGRGHYGTVYKGHLEFNDK--DQPREQVAIKMLNTMQVST--DFHRE 940
            |       .|.|    :::|:|::|:|   .|...|.  |...|.||:|.|.:.:.:|  ||.||
Zfish   808 EDVFEERYLRFI----SVLGKGNFGSV---ELCRYDPWGDNTGELVAVKELQSNKQATMADFQRE 865

  Fly   941 IGIMRTLSHPNIVKFK---YWAEK-SHCIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANG 1001
            |..:.:|....|||:|   |...: |..::||||..||...|:.....|:.|.:|:.||..|..|
Zfish   866 IQTISSLHCDYIVKYKGICYSTGRLSTKLVMEYLPYGSLIGYMEKHRHNVGNRKLLLFASQICKG 930

  Fly  1002 MKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSK-RDIPIRWYSPEA 1065
            |:||..|..:|||||||||||   ...:.|||:||||.:....|..||..:: .:.|:.||:||:
Zfish   931 MEYLQSMRYVHRDLAARNILV---ASDNLVKIADFGLTKIIPVDKEYYRVTQPGESPVFWYAPES 992

  Fly  1066 ISTCRFSSYSDVWSYGVTLFEMFSR---GEEPNLVPIQ---------TSQEDFLNRLQSGERLNR 1118
            ||..:||..|||||:|:.|.|:||.   .:.|..:.||         :.....|..|::..||..
Zfish   993 ISELKFSHKSDVWSFGIVLHELFSYCDISQNPKKLCIQKIGRYVHSPSMAIHLLTLLKNNWRLPA 1057

  Fly  1119 PASCPDFIYDLMQLCWHATPRSRPSFATIVDII 1151
            ||.||..::.:|..||.....:||||:::.|:|
Zfish  1058 PAQCPLKVHSIMMQCWEFNSENRPSFSSLKDLI 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604	49/250 (20%)
		SH2_Jak_family	420..516	CDD:198177	27/97 (28%)
		PTK_Jak_rpt1	584..836	CDD:270633	57/263 (22%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	106/294 (36%)
		TyrKc	894..1151	CDD:197581	102/277 (37%)
jak3	XP_002663133.4	B41	26..255	CDD:214604	53/272 (19%)
		FERM_C_JAK3	251..365	CDD:275413	32/171 (19%)
		SH2_Jak3	365..459	CDD:198243	29/112 (26%)
		PKc_like	521..774	CDD:304357	66/301 (22%)
		Pkinase_Tyr	521..773	CDD:285015	66/300 (22%)
		PTKc_Jak_rpt2	811..1091	CDD:270634	105/290 (36%)
		TyrKc	816..1090	CDD:197581	104/283 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3244
OMA	1	1.010	-	-		QHG47769
OrthoDB	1	1.010	-	-		D38412at33208
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		otm26318
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	10.040