DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and ptk6a

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_682778.6	Gene:	ptk6a / 555232	ZFINID:	ZDB-GENE-081105-117	Length:	563	Species:	Danio rerio

Alignment Length:	451	Identity:	121/451 - (26%)
Similarity:	192/451 - (42%)	Gaps:	104/451 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 WIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQ-----LLRQKNLD--GNIL 798
            ::|..:....|..|    .|.|.|.|     .:|.:.::..|..|.     |:|....|  |.:|
Zfish   159 FVPNHFLARRQTVK----EQPWYFGT-----LNRFETEILLLAPENDVGAFLVRHSEKDNIGYVL 214

  Fly   799 KMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLN---------TIKA-EILPNYM------ 847
            .:|                 |.|.::...|..|....|         |.:: |.|.:|.
Zfish   215 SVL-----------------SGDRSREVKHIKIHQNQNESFYLDKSQTFQSLEKLVDYYWKYSLD 262

  Fly   848 -------------PPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIG 899
                         |.|:..::.|.::..:.:.:                        :.:|..:|
Zfish   263 GDSFLKQPCRRPEPKPKDLSHSTVNDWELPKEE------------------------FTLEEELG 303

  Fly   900 RGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVS-TDFHREIGIMRTLSHPNIVK-FKYWAEKS 962
            :|.:..||:|      |.:....||||:|....:: .:|..|..|::.|.|.:::. |......|
Zfish   304 KGFFADVYRG------KWKGMVNVAIKILKNDSINHREFMLETQILKKLRHKHLIALFAVCTSSS 362

  Fly   963 -HCIIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHN 1025
             ..||.|.::.|.....|: ....:||...|...|..:|:||.||.:...|||||||||:||
Zfish   363 PFYIITELMEKGDLLSLLKGKEGQDLNAQMLTEMASQVADGMAYLEEQNSIHRDLAARNVLV--- 424

  Fly  1026 GDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSR 1090
            |.....|::|.|||:.....  .|:.....||.:|.:|||||..|||:.|||||:||.|:|||:.
Zfish   425 GANYICKVADLGLARIVKES--VYSSEDAQIPYKWSAPEAISHGRFSNKSDVWSFGVLLYEMFTY 487

  Fly  1091 GEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII 1151
            |..|  .|..::.|.: |.:.||.|:..|.:||..|||:|.:||..:...||.|:.::.::
Zfish   488 GGVP--YPAFSNIEVY-NMITSGYRMPAPPNCPSHIYDIMLMCWRYSAEERPDFSELLRLL 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	20/101 (20%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	93/270 (34%)
		TyrKc	894..1151	CDD:197581	93/260 (36%)
ptk6a	XP_682778.6	SH3_Brk	110..167	CDD:212781	1/7 (14%)
		SH2	174..261	CDD:214585	22/108 (20%)
		PKc_like	289..541	CDD:328722	93/289 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810