DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and Tyk2

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_001192241.1 Gene:Tyk2 / 54721 MGIID:1929470 Length:1207 Species:Mus musculus


Alignment Length:1329 Identity:297/1329 - (22%)
Similarity:481/1329 - (36%) Gaps:336/1329 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GRTSLADSASLTNSSLRSGTSSQSIHTNDGTIRVFNFTTGEFERFHP-------NMLCEEICNTM 74
            |...|....::...|...||.:|.: ...|.:.|.....|. |...|       ::..||:|..:
Mouse     3 GTMPLCGRRAILEDSKADGTEAQPL-VPTGCLMVLLHWPGP-EGGEPWVTFSQTSLTAEEVCIHI 65

  Fly    75 CRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCLPGERLNC--QLVYCFRMRF--------- 128
            ..::||.|....|:.:......           .|..|...|:.  .:...|||||         
Mouse    66 AHKVGITPPCLNLFALYNAQAK-----------VWLPPNHILDTSQDMNLYFRMRFYFRNWHGMN 119

  Fly   129 -RVPEL---------------DSQLELIDGRSHKFLYRQMRY----------------------- 154
             :.|.:               :..::|:|..|.::|:.|..|                       
Mouse   120 PQEPAVYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGWYVGNRAKSSHTSFSIHRSTPQGKH 184

  Fly   155 ----------DMRTEQIPEIRYPEHKDKSTGLAVMDML-------IDDQEQSEDQQAMRSIEKLY 202
                      |:.:|:  ||.:  .|::|.|:|.:.:.       :..:|.:.:......|...:
Mouse   185 EFMNDVVSLRDLSSEE--EIHH--FKNESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSF 245

  Fly   203 KLYLPPSLWRAHSFFVGSKIREVF----RSLKANSLSVERLKWHYVHQVSHLAPTYMTEQF-TCT 262
            :.::     |.|:.....::..||    |:.:...||.:.:...|:..:..|||.:.:|:. .|.
Mouse   246 RQHI-----RQHNVLTRLRLHRVFRRFLRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCH 305

  Fly   263 VQ----------YLPNE-EVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKK 316
            ::          |:.|. :.|...||          .|.|...|:  ..|.|.|..:.......:
Mouse   306 LEVLAQPERDPCYIQNSGQTAGDPGP----------ELPSGPPTH--EVLVTGTGGIQWHPLQTQ 358

  Fly   317 AKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLK------WILVGAVEGI-FMISKINDTS 374
            ...|..|.|       .||.|.......|....|...:      |......:.| .::.|.....
Mouse   359 ESERGNSRG-------NPHGSRSGKKPKAPKAGEHLTESPQEPPWTYFCDFQDISHVVLKERRVH 416

  Fly   375 VRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIG 439
            :.|:.   .|...:...::.|..||::.:..|.||::.....|||....|.|........|||:.
Mouse   417 IHLQD---NKCLLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLM 478

  Fly   440 GAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFRIVRKDSQ---- 500
            ..:...||....   |.|:::......:...:.:..:..|........:...|.|.::...    
Mouse   479 DPFVQAKLWPED---GLYLIQWSTSHLHRLILTVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLD 540

  Fly   501 -WKLSYNNGEHVLNSLHEVAHIIQADS----PDRYRIPASKYDKP-PLLLLLLPKNLKAKKTDLQ 559
             |..|:       .||.::...:|..|    .|.:.:......:| .:..|::.:..:|....|.
Mouse   541 GWGRSF-------ASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLN 598

  Fly   560 LSEAELQRRNPQIF--------NPRTDLQWY--------PDSISLSDDGMMFTMRGDWIQQSPVK 608
            ||:....|.:....        ..||::  |        ||...: |:|......|...||    
Mouse   599 LSQLSFHRVHQDEITQLSHLGQGTRTNV--YEGLLRVGGPDEGKV-DNGCPPEPGGTSGQQ---- 656

  Fly   609 DVSVTMKMLKSDGN--FMEFFRLAQTWSLIQSPQFLKLYGLTL-ADPYTMVMEYSRYGPLNKFL- 669
             :.|.:|:|....:  .:.|:..|...|.:.......|:|:.: .....:|.|:..:|||:.:| 
Mouse   657 -LRVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLR 720

  Fly   670 HSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKY----DPNSYVLDAKISDPG- 729
            .....|.:...:.:...|...:.||||..::|..:...|:.:.:.    ..|.::   |:|||| 
Mouse   721 RQRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFI---KLSDPGV 782

  Fly   730 ----YPRPYRESDSPWIPVKYY----RNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQ 786
                ..|..|....||...:..    .:|..| ||    :|.|..|:.||   |           
Mouse   783 GQGALSREERVERIPWTAPECLSGGTSSLGTA-TD----MWGFGATLLEI---C----------- 828

  Fly   787 LLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPE 851
                  .||                |..:.|....|.:||          ..|...||. ...||
Mouse   829 ------FDG----------------EAPLQGRGPSEKERF----------YTKKHQLPE-PSSPE 860

  Fly   852 IATNGTGDETVIDRSDIPFLPFPRSNMLMVI-------------------------PLTSECRVI 891
            :||        :.|..:.:.|..|.:...::                         |.....|.:
Mouse   861 LAT--------LTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYL 917

  Fly   892 YNMENMIGRGHYGTVYKGHLEFND--KDQPREQVAIKMLNT---MQVSTDFHREIGIMRTLSHPN 951
            ..:.: :|.||:|.|   .|...|  .|...|.||:|.|..   .|:.:.:.|||.|:|||.|.:
Mouse   918 KKIRD-LGEGHFGKV---SLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEH 978

  Fly   952 IVKFK----YWAEKSHCIIMEYLQSGSFDIYLRFTAPNLNNPR-------LVSFALDIANGMKYL 1005
            |||:|    ...|||..::|||:..||...||         ||       |:.||..|..||.||
Mouse   979 IVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL---------PRHCVGLAQLLLFAQQICEGMAYL 1034

  Fly  1006 SDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDG--YYYAKSKRDIPIRWYSPEAIST 1068
            .....|||||||||:|:|::   ..|||.|||||: |..:|  ||..:...|.|:.||:||.:..
Mouse  1035 HAQHYIHRDLAARNVLLDND---RLVKIGDFGLAK-AVPEGHEYYRVREDGDSPVFWYAPECLKE 1095

  Fly  1069 CRFSSYSDVWSYGVTLFEMFS---RGEEPN-----LVPIQTSQEDFL---NRLQSGERLNRPASC 1122
            |:|...|||||:||||:|:.:   ..:.|:     |:.....|...|   ..|:.||||.||..|
Mouse  1096 CKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRC 1160

  Fly  1123 PDFIYDLMQLCWHATPRSRPSFATIVDII 1151
            |..||.||:.||......||:|..:|.|:
Mouse  1161 PCEIYHLMKNCWETEASFRPTFQNLVPIL 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604 50/297 (17%)
SH2_Jak_family 420..516 CDD:198177 15/100 (15%)
PTK_Jak_rpt1 584..836 CDD:270633 55/268 (21%)
PTKc_Jak_rpt2 886..1155 CDD:270634 112/295 (38%)
TyrKc 894..1151 CDD:197581 110/285 (39%)
Tyk2NP_001192241.1 B41 45..299 CDD:214604 44/273 (16%)
PH-like 296..459 CDD:302622 34/184 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..391 19/92 (21%)
SH2 459..557 CDD:301589 16/107 (15%)
PKc_like 612..887 CDD:304357 69/345 (20%)
Pkinase_Tyr 612..886 CDD:285015 69/344 (20%)
PTKc_Tyk2_rpt2 912..1194 CDD:270664 112/295 (38%)
TyrKc 917..1189 CDD:197581 110/288 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 247 1.000 Inparanoid score I3247
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47769
OrthoDB 1 1.010 - - D38412at33208
OrthoFinder 1 1.000 - - FOG0001105
OrthoInspector 1 1.000 - - otm42587
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45807
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X669
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1010.080

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