DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and lyn

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001004543.1	Gene:	lyn / 447804	ZFINID:	ZDB-GENE-040912-7	Length:	510	Species:	Danio rerio

Alignment Length:	263	Identity:	92/263 - (34%)
Similarity:	138/263 - (52%)	Gaps:	19/263 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   894 MENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREIGIMRTLSHPNIVKFK 956
            |...:|.|.:|.|:......:.|      ||:|.|  .||.|.. |..|..:|:||.|..:|:..
Zfish   247 MVKKLGAGQFGEVWMAFYNNSTK------VAVKTLKPGTMSVEA-FLEEANLMKTLQHDRLVRLY 304

  Fly   957 YWAEKSH--CIIMEYLQSGSFDIYLRFTA-PNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAAR 1018
            ....|:.  .||.||:.:||...:|:..| ..:..|:|:.|:..||.||.|:.....|||||.|.
Zfish   305 AVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQIAEGMAYIEKKNYIHRDLRAA 369

  Fly  1019 NILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVT 1083
            |:||   .:....||:|||||:....| .|.|:.....||:|.:||||:...|:..||:||:||.
Zfish   370 NVLV---SEMLLCKIADFGLARVIEDD-QYTAREGAKFPIKWTAPEAINYGSFTIKSDMWSFGVL 430

  Fly  1084 LFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIV 1148
            |:|:.:.|:.|  .| ..|..:.::.:|.|.|:.||.:||..:|::|..||...|..||:|..|.
Zfish   431 LYEIITYGKIP--YP-GMSNSEVMSSVQRGYRMPRPENCPVELYEIMTTCWKNKPEDRPTFDYIQ 492

  Fly  1149 DII 1151
            .::
Zfish   493 SVL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633
		PTKc_Jak_rpt2	886..1155	CDD:270634	92/263 (35%)
		TyrKc	894..1151	CDD:197581	92/261 (35%)
lyn	NP_001004543.1	SH3_Lyn	65..120	CDD:212937
		SH2_Src_Lyn	123..223	CDD:198227
		PTKc_Lyn	237..508	CDD:270657	92/263 (35%)
		Pkinase_Tyr	245..495	CDD:285015	92/261 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900