DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and MATK

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_002369.2	Gene:	MATK / 4145	HGNCID:	6906	Length:	508	Species:	Homo sapiens

Alignment Length:	296	Identity:	101/296 - (34%)
Similarity:	156/296 - (52%)	Gaps:	33/296 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   891 IYNMENM-----IGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHREIGIMRTLSHP 950
            :.|::::     ||.|.:|.|.:|       :...::||:|.:.....:..|..|..:|..:.|.
Human   230 LLNLQHLTLGAQIGEGEFGAVLQG-------EYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 287

  Fly   951 NIVK-FKYWAEKSHCIIMEYLQSGSFDIYLRFTAPNL-NNPRLVSFALDIANGMKYLSDMGLIHR 1013
            |:|: ......:...|:||::..|:...:||.....| |..:|:.|:|.:|.||:||....|:||
Human   288 NLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHR 352

  Fly  1014 DLAARNILVDHNGDGDCV-KISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDV 1077
            |||||||||..    |.| |:||||||: |...|   ..|.| :|::|.:|||:...:|:|.|||
Human   353 DLAARNILVSE----DLVAKVSDFGLAK-AERKG---LDSSR-LPVKWTAPEALKHGKFTSKSDV 408

  Fly  1078 WSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRP 1142
            ||:||.|:|:||.|..|  .| :.|.::....::.|.|:..|..||..::.||..||.|.|..||
Human   409 WSFGVLLWEVFSYGRAP--YP-KMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470

  Fly  1143 SFATIVDIITREV------ATKVTHPTDGHQSPPNQ 1172
            .|..:.:.:.||:      |:......||..||.:|
Human   471 PFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633
		PTKc_Jak_rpt2	886..1155	CDD:270634	94/271 (35%)
		TyrKc	894..1151	CDD:197581	92/264 (35%)
MATK	NP_002369.2	SH3_CHK	51..109	CDD:212745
		SH3 domain	55..106
		SH2_csk_like	119..216	CDD:198190
		SH2 domain	123..213
		PTKc_Chk	229..482	CDD:270666	93/270 (34%)
		catalytic domain	236..479		92/261 (35%)
		STYKc	236..479	CDD:214568	92/261 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810