DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and Csk

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	94/259 - (36%)
Similarity:	140/259 - (54%)	Gaps:	25/259 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   894 MENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHREIGIMRTLSHPNIVKF--K 956
            :...||:|.:|.|..|.|.       .|:||:|||........|..|..:|.||.|.|:|||  .
  Fly   802 LRESIGKGEFGDVMLGILR-------NEKVAVKMLKDEGAVQKFLAEASVMTTLEHDNLVKFIGL 859

  Fly   957 YWAEKSHCIIMEYLQSGSFDIYLRFTA-PNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNI 1020
            .:..|...::.||:..||...|||... .::.....:.||.|.|:||:||....::||||||||:
  Fly   860 VFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNV 924

  Fly  1021 LVDHNGDGDCV-KISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTL 1084
            |:..    ||| |:||||||:   .:.|.....|  :||:|.:|||:...|||:.||:||:|:.|
  Fly   925 LISE----DCVAKVSDFGLAR---EECYNLDVGK--LPIKWTAPEALKNGRFSNKSDMWSFGILL 980

  Fly  1085 FEMFSRGEEP-NLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATI 1147
            :|::|.|..| ..:|:    .|.:..::.|.::..|..||..||::|:..|...|..||:||.:
  Fly   981 WEIYSFGRVPYPRIPL----ADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633
		PTKc_Jak_rpt2	886..1155	CDD:270634	94/259 (36%)
		TyrKc	894..1151	CDD:197581	94/259 (36%)
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190
		PTKc_Csk_like	793..1047	CDD:270635	94/259 (36%)
		STYKc	800..1044	CDD:214568	94/259 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810