DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and LCK

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_024302814.1	Gene:	LCK / 3932	HGNCID:	6524	Length:	567	Species:	Homo sapiens

Alignment Length:	622	Identity:	159/622 - (25%)
Similarity:	255/622 - (40%)	Gaps:	160/622 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   597 MRGDWIQQSPVKDVSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLTLADPYTMVMEYSR 661
            ::||..||. :||        |:.|:....|.|:.|:       ||.  ||....|:.:...:.
Human    61 LQGDPRQQG-LKD--------KACGSLAVGFHLSPTY-------FLP--GLAFLVPHPVTPGFL- 106

  Fly   662 YGPLNKFLHSMPNVTLHCLLDLMH----------GLVRG--MHYLEDNKIIHNYIRCSNLYVTK- 713
              |:......||.|....|:..:|          |..:|  :..||.:   ..:.:..:|...:
Human   107 --PIPARFSLMPLVFTDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS---GEWWKAQSLTTGQE 166

  Fly   714 -YDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKE 777
             :.|.::|..|...:|          .||    :::||.                        ::
Human   167 GFIPFNFVAKANSLEP----------EPW----FFKNLS------------------------RK 193

  Fly   778 DLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDI----------- 831
            |    .:.|||...|..|:.|  :.:....|..|...:..:..::.:...|:.|
Human   194 D----AERQLLAPGNTHGSFL--IRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYIS 252

  Fly   832 ----FSRLNTIKAEILPNYMPPPEIATNGT-GDETVIDR---SDIPFLPF-------PRSNMLMV 881
                |..|:    |::.:|       ||.: |..|.:.|   :..|..|:       ||..:.:|
Human   253 PRITFPGLH----ELVRHY-------TNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLV 306

  Fly   882 IPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTD-FHREIGIMR 945
                          ..:|.|.:|.|:.|:...:.|      ||:|.|....:|.| |..|..:|:
Human   307 --------------ERLGAGQFGEVWMGYYNGHTK------VAVKSLKQGSMSPDAFLAEANLMK 351

  Fly   946 TLSHPNIVK-FKYWAEKSHCIIMEYLQSGSFDIYLRFTAPN---LNNPRLVSFALDIANGMKYLS 1006
            .|.|..:|: :....::...||.||:::||...:|:  .|:   |...:|:..|..||.||.::.
Human   352 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLK--TPSGIKLTINKLLDMAAQIAEGMAFIE 414

  Fly  1007 DMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRF 1071
            :...|||||.|.||||   .|....||:|||||:.. .|..|.|:.....||:|.:||||:...|
Human   415 ERNYIHRDLRAANILV---SDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAINYGTF 475

  Fly  1072 SSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHA 1136
            :..|||||:|:.|.|:.:.|..|  .|..|:.| .:..|:.|.|:.||.:||:.:|.||:|||..
Human   476 TIKSDVWSFGILLTEIVTHGRIP--YPGMTNPE-VIQNLERGYRMVRPDNCPEELYQLMRLCWKE 537

  Fly  1137 TPRSRPSFATIVDIITREVATKVTHPTDGHQSPPNQP 1173
            .|..||:|..:     |.|.......|:|...|  ||
Human   538 RPEDRPTFDYL-----RSVLEDFFTATEGQYQP--QP 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	47/267 (18%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	93/273 (34%)
		TyrKc	894..1151	CDD:197581	92/261 (35%)
LCK	XP_024302814.1	SH3_Lck	123..176	CDD:212938	9/55 (16%)
		SH2_Src_Lck	181..281	CDD:198225	24/154 (16%)
		PTKc_Lck_Blk	295..558	CDD:270652	97/296 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810