DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and JAK1

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_001307852.1 Gene:JAK1 / 3716 HGNCID:6190 Length:1154 Species:Homo sapiens


Alignment Length:1246 Identity:298/1246 - (23%)
Similarity:483/1246 - (38%) Gaps:301/1246 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 TGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTS--RRPSPLVRLDLTWCLPGERLN 117
            :||:       ..||:|....:...|:|:...|:.:.:.:|.  ..|:..:.:|       ::::
Human    52 SGEY-------TAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVD-------DKMS 102

  Fly   118 CQLVYCFRMRF------------------------------RVPELDSQLELIDGRSHKFLYRQM 152
            .:|.|  ||||                              ::|:   ...|:|..|.::|:.|.
Human   103 LRLHY--RMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPD---ATPLLDASSLEYLFAQG 162

  Fly   153 RYDMRTEQIPEIRYPE-----H--KDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKL--------Y 202
            :||: .:.:..||.|:     |  :::..|:||:.:         ...||....:|        |
Human   163 QYDL-VKCLAPIRDPKTEQDGHDIENECLGMAVLAI---------SHYAMMKKMQLPELPKDISY 217

  Fly   203 KLYLPPSL---WRAHSFFVGSKIREVFRS-LKA--------NSLSVERLKWHYVHQVSHLAPTYM 255
            |.|:|.:|   .|..:.....:|..||:. ||.        :|:|...||..|:..:..|...|.
Human   218 KRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYG 282

  Fly   256 TEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNT---------NSVALG 311
            .|.|..::..:.:|.        ..:..||.    ..|:......:.|..         |.|::.
Human   283 AEIFETSMLLISSEN--------EMNWFHSN----DGGNVLYYEVMVTGNLGIQWRHKPNVVSVE 335

  Fly   312 GSGKKAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEGIFMISKINDTSVR 376
            ....|.||:....         .|...|...|:..       :|      .......:|....::
Human   336 KEKNKLKRKKLEN---------KHKKDEEKNKIRE-------EW------NNFSYFPEITHIVIK 378

  Fly   377 LEIVGL----PKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGP 437
            ..:|.:    .|..|::..:.:|..||:|.:..|.||::.....||.....|.:.......||||
Human   379 ESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGP 443

  Fly   438 IGGAYSLMKLHENGDKCGSYIVR-ECDREYNIYYIDINTKIMAKKTDQERCKTETFRIVRKDSQ- 500
            |...|::.||.:.|.:.|.|::| .|....||    :.|....:|::|.:...:.|:..:.:.| 
Human   444 ICTEYAINKLRQEGSEEGMYVLRWSCTDFDNI----LMTVTCFEKSEQVQGAQKQFKNFQIEVQK 504

  Fly   501 WKLSYNNGEHVLNSL-----HEVAHIIQADSPDRYRIPASKYDKPPLLLLLLPKNLKAK------ 554
            .:.|.:..:....||     |....|::.|:.. :.:......||..:..||....||:      
Human   505 GRYSLHGSDRSFPSLGDLMSHLKKQILRTDNIS-FMLKRCCQPKPREISNLLVATKKAQEWQPVY 568

  Fly   555 -----------KTDLQLSEAELQRRNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPVK 608
                       |.||...|...:.....|::  ..|..|.|     |:|           .|..|
Human   569 PMSQLSFDRILKKDLVQGEHLGRGTRTHIYS--GTLMDYKD-----DEG-----------TSEEK 615

  Fly   609 DVSVTMKMLKSDGN--FMEFFRLAQTWSLIQSPQFLKLYGLTLAD-PYTMVMEYSRYGPLNKFLH 670
            .:.|.:|:|.....  .:.||..|.....:.....:.|||:.:.| ...||.|:...|||:.|:|
Human   616 KIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH 680

  Fly   671 SMPNV-TLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNS----YVLDAKISDPGY 730
            ...:| |......:...|...:.||||..::|..:...||.:.:...:|    ::   |:||||.
Human   681 RKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFI---KLSDPGI 742

  Fly   731 P-----RPYRESDSPWIP---VKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQL 787
            |     |.......|||.   |:..:||..|     |..|:|.||::||   |......|:.:.|
Human   743 PITVLSRQECIERIPWIAPECVEDSKNLSVA-----ADKWSFGTTLWEI---CYNGEIPLKDKTL 799

  Fly   788 LRQ---------------KNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNT 837
            :.:               |.|...:.:.::.|....|.|..||             .|| ::|..
Human   800 IEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIM-------------RDI-NKLEE 850

  Fly   838 IKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGH 902
            ...:|:....|..|:      |.|..::.   ||...|.                     :|.||
Human   851 QNPDIVSEKKPATEV------DPTHFEKR---FLKRIRD---------------------LGEGH 885

  Fly   903 YGTVYKGHLEFNDKDQPREQVAIKMLNTMQVS---TDFHREIGIMRTLSHPNIVKFKYWAEKSHC 964
            :|.|.....: .:.|...||||:|.|......   .|..:||.|:|.|.|.||||:     |..|
Human   886 FGKVELCRYD-PEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY-----KGIC 944

  Fly   965 ---------IIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNI 1020
                     :|||:|.|||...||......:|..:.:.:|:.|..||.||.....:||||||||:
Human   945 TEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNV 1009

  Fly  1021 LVDHNGDGDCVKISDFGLAQFANSD-GYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTL 1084
            ||:....   |||.||||.:...:| .||..|..||.|:.||:||.:...:|...|||||:||||
Human  1010 LVESEHQ---VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTL 1071

  Fly  1085 FEMFSRGEEPN---------LVPI--QTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATP 1138
            .|:.:..:..:         :.|.  |.:....:|.|:.|:||..|.:|||.:|.||:.||...|
Human  1072 HELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP 1136

  Fly  1139 RSRPSFATIVD 1149
            .:|.||..:::
Human  1137 SNRTSFQNLIE 1147

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604 54/262 (21%)
SH2_Jak_family 420..516 CDD:198177 24/102 (24%)
PTK_Jak_rpt1 584..836 CDD:270633 67/282 (24%)
PTKc_Jak_rpt2 886..1155 CDD:270634 100/288 (35%)
TyrKc 894..1151 CDD:197581 100/280 (36%)
JAK1NP_001307852.1 B41 37..286 CDD:214604 54/262 (21%)
FERM_C_JAK1 282..426 CDD:275412 29/177 (16%)
SH2 426..527 CDD:301589 25/104 (24%)
PTK_Jak1_rpt1 583..846 CDD:270662 72/305 (24%)
Pkinase_Tyr 583..845 CDD:285015 70/303 (23%)
PTKc_Jak1_rpt2 870..1153 CDD:173644 103/311 (33%)
TyrKc 875..1149 CDD:197581 102/303 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 246 1.000 Inparanoid score I3279
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47769
OrthoDB 1 1.010 - - D38412at33208
OrthoFinder 1 1.000 - - FOG0001105
OrthoInspector 1 1.000 - - otm40514
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45807
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X669
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.940

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