DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Bmx

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001102486.1	Gene:	Bmx / 367786	RGDID:	1565643	Length:	655	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	131/499 - (26%)
Similarity:	211/499 - (42%)	Gaps:	106/499 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   721 LDAKISD---PGYPRPYRES-DS-PWIPVKYY---------------------------RNLQAA 753
            :||..|.   |.|....::| || |.:.::|.                           ||:.:.
  Rat   186 MDASSSSAIPPQYDSHLKKSYDSQPTVNIRYIPREDCPDWWQIRKPKSEEDIARSNQLERNIVSH 250

  Fly   754 KTDQFAQLWAFATT----------IYEIFSRCKEDLSTLRQEQLLRQKNLDGNIL--KMLDQDIC 806
            ...:.:  |.|..:          .|:.|:   .::|..:.|||||||..:|..:  ......:.
  Rat   251 SPSKMS--WGFPESSSSEEEENLDAYDWFA---GNISRSQSEQLLRQKGKEGAFMVRNSSQMGMY 310

  Fly   807 PAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNY---MPPPEIATNGTGDETVIDRSDI 868
            ...:|...:    :|:.....|:.:.:.... |..:..||   ..|..|..:......:|.|
  Rat   311 TVSLFSKAV----NDKKGTVKHYHVHTNAEN-KLYLAENYCFDSIPKLIHYHQHNSAGMITR--- 367

  Fly   869 PFLPFPRSNMLMVIPLT------------SECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPRE 921
              |..|.|.....:|::            .|..::    ..:|.|.:|.|..|      |.:.:.
  Rat   368 --LRHPVSTKANKVPVSVALGSGIWELKREEIALL----KELGSGQFGVVQLG------KWKGQY 420

  Fly   922 QVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVKFKYWAEKSH--CIIMEYLQSGSFDIYLRFTA 983
            .||:||:....:|.| |.:|...|..||||.:|||.....|.:  .|:.||:.:|....||:...
  Rat   421 SVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKNHG 485

  Fly   984 PNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYY 1048
            ..|.:.:|:....|:..||.:|.....|||||||||.|||.:..   ||:||||:.::...|.|.
  Rat   486 KGLESSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLS---VKVSDFGMTRYVLDDQYV 547

  Fly  1049 YAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEP------NLVPIQTSQEDFL 1107
            .:...: .|::|.:||.....::||.||||::|:.::|:||.|::|      :.|.::.||
  Rat   548 SSVGTK-FPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQ---- 607

  Fly  1108 NRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII 1151
                 |.||.||....|.||.:|..|||..|..||:|..::..|
  Rat   608 -----GHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAI 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	28/158 (18%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	92/275 (33%)
		TyrKc	894..1151	CDD:197581	90/265 (34%)
Bmx	NP_001102486.1	PH_Btk	25..151	CDD:269944
		PH	27..115	CDD:278594
		SH2_Tec_Bmx	269..374	CDD:198262	23/117 (20%)
		PKc_like	392..647	CDD:304357	92/278 (33%)
		Pkinase_Tyr	397..646	CDD:285015	90/271 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900