DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Itk

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001102295.2	Gene:	Itk / 363577	RGDID:	1311618	Length:	620	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	174/749 - (23%)
Similarity:	287/749 - (38%)	Gaps:	198/749 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 YIDINTKIMAKKTDQERCKTETFR----IVRKDSQWKLSYNNGEH----VLNSLHEVA-----HI 521
            :|.:..:::.|...:.|.....|:    ::.|.|   |:|....|    .|....|::     .|
  Rat     4 FILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKAS---LAYFEDRHGKKRTLKGSIELSRIKCVEI 65

  Fly   522 IQAD--SPDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQLSEAELQRRNPQIFNPRTDLQWYPD 584
            :::|  .|..|:.|........||.:..|.....::..|.|.|   :.||    |.....:::|:
  Rat    66 VKSDISIPCHYKYPFQVMHDNYLLYVFAPDCESRQRWVLTLKE---ETRN----NNSLVSKYHPN 123

  Fly   585 SISLSDDGMMFTMRGDW-------------IQQSPVKDVSVTMKMLKSDGNFMEFFRLAQTWSLI 636
                      |.|.|.|             ....|.|:.|........:.|...|
  Rat   124 ----------FWMDGRWRCCSQLEKLAVGCAPYDPTKNASKKPLPPTPEDNRRSF---------- 168

  Fly   637 QSPQ---FLKLYGLTLADPYTMVM----EYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYL 694
            |.|:   .:.||.....||..:.:    ||                                 ||
  Rat   169 QEPEETLVIALYDYQTNDPQELALRRDEEY---------------------------------YL 200

  Fly   695 EDNKIIHNY-IRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQF 758
            .|:..||.: ::..|.: ..|.|:||:::   ..|.....|.     |    |.:::...|.::.
  Rat   201 LDSSEIHWWRVQDKNGH-EGYAPSSYLVE---KSPNSLETYE-----W----YNKSISRDKAEKL 252

  Fly   759 ----AQLWAF--------ATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIF 811
                .:..||        .|....:|::.           ::.:.|                |..
  Rat   253 LLDTGKEGAFMVRDSRTPGTYTVSVFTKA-----------IISENN----------------PCI 290

  Fly   812 ETIMDGWSDDETKRF--SHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFP 874
            :......::|..||:  :...:|..:     .:|..|.     ..||.|   ::.|     |.:|
  Rat   291 KHYHIKETNDSPKRYYVAEKYVFDSI-----PLLIQYH-----QYNGGG---LVTR-----LRYP 337

  Fly   875 RSNMLMVIPLTSECR----VIYNME----NMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTM 931
            ..:.....|:|:..|    ||...|    ..||.|.:|.|:.|:....||      ||||.:...
  Rat   338 VCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDK------VAIKTIQEG 396

  Fly   932 QVS-TDFHREIGIMRTLSHPNIVK-FKYWAEKSH-CIIMEYLQSGSFDIYLRFTAPNLNNPRLVS 993
            .:| .||..|..:|..||||.:|: :....|::. |::.|:::.|....|||..........|:.
  Rat   397 AMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLG 461

  Fly   994 FALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPI 1058
            ..||:..||.||....:|||||||||.||   |:...:|:||||:.:|. .|..|.:.:....|:
  Rat   462 MCLDVCEGMAYLEKACVIHRDLAARNCLV---GENQVIKVSDFGMTRFV-LDDQYTSSTGTKFPV 522

  Fly  1059 RWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQT-SQEDFLNRLQSGERLNRPASC 1122
            :|.|||..|..|:||.|||||:||.::|:||.|:    :|.:. |..:.:..:.:|.||.:|...
  Rat   523 KWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGK----IPYENRSNSEVVEDISTGFRLYKPRLA 583

  Fly  1123 PDFIYDLMQLCWHATPRSRPSFATIVDIITREVA 1156
            ...:|.:|..||...|..||.|:.::..:. |:|
  Rat   584 SPHVYQVMNHCWKEKPEDRPPFSRLLSQLA-EIA 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177	10/53 (19%)
		PTK_Jak_rpt1	584..836	CDD:270633	42/286 (15%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	94/280 (34%)
		TyrKc	894..1151	CDD:197581	91/264 (34%)
Itk	NP_001102295.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900