DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and src

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_017209008.1	Gene:	src / 325084	ZFINID:	ZDB-GENE-030131-3809	Length:	549	Species:	Danio rerio

Alignment Length:	465	Identity:	126/465 - (27%)
Similarity:	201/465 - (43%)	Gaps:	90/465 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 NSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQL-----WAFATTIYEIFSRCK 776
            |:..|:.:..|....|.....:|.:||..|.....:.:.:...:|     |.|.    :|..|..
Zfish   114 NTRKLNPREGDWWLARSLTTGESGYIPSNYVAPSDSIQAEDHLRLTLEKRWYFG----KITRRDS 174

  Fly   777 EDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDI---------- 831
            |.|       ||..:|..|..| :.:.:........:::| :.:.:.....|:.|
Zfish   175 ERL-------LLNLENRRGTFL-VRESETTKGAYCLSVLD-YDNVKGLNVKHYKIRKLDSGGFYI 230

  Fly   832 -----FSRLNTI--------------KAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSN 877
                 ||.|..:              ..::.|...||    |.|...:.         ...||.:
Zfish   231 TSRTQFSTLQQLVNHYRQHADGLCHSLTDVCPVLKPP----TQGLARDA---------WEIPRDS 282

  Fly   878 MLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTD-FHREI 941
            :.:.:.|              |:|.:|.|:.|  .:|.    ..:||||.|....:|.: |.:|.
Zfish   283 LRLDVKL--------------GQGCFGEVWMG--TWNG----TTRVAIKTLKPGTMSPEAFLQEA 327

  Fly   942 GIMRTLSHPNIVK-FKYWAEKSHCIIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKY 1004
            .:|:.|.|..:|: :...:|:...|:.||:..||...:|: .....|..|:||..|..||:||.|
Zfish   328 QVMKKLRHEKLVQLYAVVSEEPIYIVTEYMGQGSLLDFLKGDMGKMLRLPQLVDMASQIASGMAY 392

  Fly  1005 LSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTC 1069
            :..|..:||||.|.||||   ||....|::|||||:.. .|..|.|:.....||:|.:|||....
Zfish   393 VERMNYVHRDLRAANILV---GDNLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTAPEAALYG 453

  Fly  1070 RFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCW 1134
            ||:..|||||:|:.|.|:.::|..|  .|...::| .|::::.|.|:..||.|||.:::||..||
Zfish   454 RFTIKSDVWSFGILLTELTTKGRVP--YPGMVNRE-VLDQVERGYRMPCPAECPDSLHELMLTCW 515

  Fly  1135 HATPRSRPSF 1144
            ...|..||:|
Zfish   516 RKEPEERPTF 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	25/138 (18%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	92/262 (35%)
		TyrKc	894..1151	CDD:197581	92/254 (36%)
src	XP_017209008.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910