DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and Csk

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001025210.1	Gene:	Csk / 315707	RGDID:	1308800	Length:	450	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	130/469 - (27%)
Similarity:	204/469 - (43%)	Gaps:	111/469 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 VTKYDPNSYVLDAKISDPG-YPRPY---RE--------SDSPWIPVKYYRN-----LQAAKTDQF 758
            ||| |||.|....|:...| .|..|   ||        |..||...|..|.     |...:|..|
  Rat    41 VTK-DPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLF 104

  Fly   759 AQLWAFATTI---YEIFSRCKEDLSTLRQEQLLRQKNLD-----GNILKMLDQDICPAPIFETIM 815
              |...:|..   |.:...|:..:...|......:.::|     .|::::::.       :.|..
  Rat   105 --LVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEH-------YTTDA 160

  Fly   816 DGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLM 880
            ||             :.:||  ||.:::.        .|....||            |.||...:
  Rat   161 DG-------------LCTRL--IKPKVME--------GTVAAQDE------------FYRSGWAL 190

  Fly   881 VIPLTSECRVIYNMENM-----IGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHRE 940
                        ||:.:     ||:|.:|.|..|       |....:||:|.:.....:..|..|
  Rat   191 ------------NMKELKLLQTIGKGEFGDVMLG-------DYRGNKVAVKCIKNDATAQAFLAE 236

  Fly   941 IGIMRTLSHPNIVKF--KYWAEKSHC-IIMEYLQSGSFDIYLRFTAPN-LNNPRLVSFALDIANG 1001
            ..:|..|.|.|:|:.  ....||... |:.||:..||...|||....: |....|:.|:||:...
  Rat   237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301

  Fly  1002 MKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAI 1066
            |:||.....:||||||||:||   .:.:..|:|||||.:.|:|     .:....:|::|.:|||:
  Rat   302 MEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASS-----TQDTGKLPVKWTAPEAL 358

  Fly  1067 STCRFSSYSDVWSYGVTLFEMFSRGEEP-NLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLM 1130
            ...:||:.|||||:|:.|:|::|.|..| ..:|:    :|.:.|::.|.:::.|..||..:||:|
  Rat   359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL----KDVVPRVEKGYKMDAPDGCPPAVYDVM 419

  Fly  1131 QLCWHATPRSRPSF 1144
            :.|||....:||:|
  Rat   420 KNCWHLDAATRPTF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	32/149 (21%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	89/269 (33%)
		TyrKc	894..1151	CDD:197581	88/261 (34%)
Csk	NP_001025210.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41240	9..70		12/29 (41%)
		SH3_CSK	11..67	CDD:212703	11/26 (42%)
		SH2_csk_like	78..175	CDD:198190	22/128 (17%)
		PTKc_Csk	188..443	CDD:133213	89/277 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810