DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and HCK

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_002101.2 Gene:HCK / 3055 HGNCID:4840 Length:526 Species:Homo sapiens


Alignment Length:432 Identity:117/432 - (27%)
Similarity:189/432 - (43%) Gaps:68/432 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   741 WIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDI 805
            :||..|...:.:.:|::    |.|.       ...::|    .:.|||...|:.|:.: :.|.:.
Human   127 YIPSNYVARVDSLETEE----WFFK-------GISRKD----AERQLLAPGNMLGSFM-IRDSET 175

  Fly   806 CPAPIFETI--MDGWSDDETKRF------------SHHDIFSRLNTIKAEILPNYMPPPEIATNG 856
            .......::  .|....|..|.:            |....||.|.    |::.:|.         
Human   176 TKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQ----ELVDHYK--------- 227

  Fly   857 TGDETVIDRSDIPFLPF----PRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKD 917
            .|::.:..:..:|.:..    |.......||     |....:|..:|.|.:|.|:......:.| 
Human   228 KGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP-----RESLKLEKKLGAGQFGEVWMATYNKHTK- 286

  Fly   918 QPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVKFKYWAEKSHC-IIMEYLQSGSFDIYLR 980
                 ||:|.:....:|.: |..|..:|:||.|..:||......|... ||.|::..||...:|:
Human   287 -----VAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLK 346

  Fly   981 FTAPNLNN-PRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANS 1044
            ....:... |:|:.|:..||.||.::.....|||||.|.||||  :....| ||:|||||:.. .
Human   347 SDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILV--SASLVC-KIADFGLARVI-E 407

  Fly  1045 DGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNR 1109
            |..|.|:.....||:|.:||||:...|:..|||||:|:.|.|:.:.|..|  .| ..|..:.:..
Human   408 DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP--YP-GMSNPEVIRA 469

  Fly  1110 LQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII 1151
            |:.|.|:.||.:||:.:|::|..||...|..||:|..|..::
Human   470 LERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604
SH2_Jak_family 420..516 CDD:198177
PTK_Jak_rpt1 584..836 CDD:270633 19/108 (18%)
PTKc_Jak_rpt2 886..1155 CDD:270634 90/269 (33%)
TyrKc 894..1151 CDD:197581 89/259 (34%)
HCKNP_002101.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SH3 82..137 CDD:302595 3/9 (33%)
SH2_Src_HCK 140..243 CDD:198226 21/131 (16%)
PKc_like 254..524 CDD:304357 92/276 (33%)
Pkinase_Tyr 262..511 CDD:285015 89/261 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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