DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and jak2a

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_571168.1	Gene:	jak2a / 30307	ZFINID:	ZDB-GENE-980526-481	Length:	1095	Species:	Danio rerio

Alignment Length:	1220	Identity:	316/1220 - (25%)
Similarity:	505/1220 - (41%)	Gaps:	280/1220 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGI-REHSTSRRPSPLVRLDLTWCLPG 113
            |.::..||:       ..||:..|..:|.|::|:...|:|: ||.            |..| ||.
Zfish    31 VISYPAGEY-------TAEELSVTAAKQCGVSPVHCALFGLMRER------------DRVW-LPP 75

  Fly   114 ERL-----NCQLVYCFRMRFRVP---------------ELDSQLELIDGRSHKFLYRQMRYDMRT 158
            ..:     :......||:||..|               ...|:..:.|..:..:|..|.|.|..:
Zfish    76 NHIFKIEPSANETLLFRVRFYFPGWYGSGCSSARRYGLSRSSEAPVCDDITTAYLCAQWRSDFLS 140

  Fly   159 EQIPEIRYPEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPPSLWRAH----SFFVG 219
            ..:......|.:::..||||:|::...:|:.:....:.: ...||.:||.:: |.|    .....
Zfish   141 GAVSVPVSLEFQEECLGLAVLDIMRLAKEKGKSPVDIYN-HSSYKSFLPKNM-REHIQNQHLVTR 203

  Fly   220 SKIREVFR-------SLKANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGP 277
            .:||..||       |.||   :...||..||..:..|.|.:.:|.|..:.
Zfish   204 KRIRFRFRRFLQQFGSCKA---APRELKLKYVVSLETLQPAFYSEHFRVSE-------------- 251

  Fly   278 IGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRRSTSGGIDVYVRVFPHDSLEPGL 342
                        ||:||...          |..|..|.:..|.:.....|:.|.....|.::  :
Zfish   252 ------------ASAGSVTI----------VVSGDRGIQWCRAAAPEPEDLQVYCDFSDVID--I 292

  Fly   343 KVARVTSEATLKWILVGAVEGIFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYI 407
            .:.:.|.:        |:||...:.....|:..          .|::||:..|..||:|.:..|.
Zfish   293 SIKQGTKD--------GSVENRIVTINRQDSQT----------LELEFQSLSEALSFVSLIDGYY 339

  Fly   408 RLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYID 472
            ||::.....||.....|.|.|...::||||:...:::.:|.....:.|.||:|...::|:.|::.
Zfish   340 RLTTDAHHYLCKEVAPPRLLEAIQINCHGPLSTEFAVSRLRRCEGQPGVYILRCSPKDYDRYFLS 404

  Fly   473 INTKIMAKKTDQERCKTETFRIVRKDSQWKLSY------NNGEHVL-------NSLHEV------ 518
            .                    :|..:.|.:|.:      .:||.||       :||.|:
Zfish   405 F--------------------MVEAEGQLELKHCLVLRSLSGEFVLSGARCSFSSLSELLARYQK 449

  Fly   519 ------AHIIQADSPDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQLSEAELQRRNPQIFNP-- 575
                  .|:.|.    |...|....||..||:....:.     :::....:|.:..|..||:.
Zfish   450 EALRSDTHVFQL----RRCCPPRSKDKSNLLVCRTHQG-----SEVCAPSSEHRLVNQMIFHKIH 505

  Fly   576 RTDLQWYPDSISLSDDGM---MFTM--------RGDWIQQSPVKDVSVTMKML-KSDGNFME-FF 627
            |.|||        :.:|:   .||.        .||:   ..|..:.|.||:| ||..|:.| ||
Zfish   506 REDLQ--------TTEGLGQGTFTQVFRGIRREVGDY---GEVHKMEVVMKILDKSHRNYTESFF 559

  Fly   628 RLAQTWSLIQSPQFLKLYGLTL-ADPYTMVMEYSRYGPLNKFLHSMPN-VTLHCLLDLMHGLVRG 690
            ..|...|.:.....|..||:.: ||.:.||.||.|:|.|:.:|....| :.:...|::...|...
Zfish   560 ESASMMSQLSHKHLLLNYGICVCADEHIMVQEYVRFGSLDTYLKRNRNTINITWKLEVAKQLAWA 624

  Fly   691 MHYLEDNKIIHNYIRCSNLYVTKYDPNS-----YVLDAKISDPG-----YPRPYRESDSPWIP-- 743
            :|:||:..:.|..:...|:.||:.:...     ::   |:||||     .||.......||:|
Zfish   625 LHHLEEKSLTHGNVCARNVLVTREEDRKTGTPPFI---KLSDPGISITVQPREILLERIPWVPPE 686

  Fly   744 -VKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICP 807
             ||..|||..|     |..|:|.||::||:  |       ..||.|...:....:|...|:...|
Zfish   687 CVKDSRNLSLA-----ADKWSFGTTLWEIY--C-------GGEQPLAAYDTAKKLLFYEDKHQLP 737

  Fly   808 AP-------IFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDR 865
            ||       :..:.||   .:...|.|...:...||::       |.|..|:...   .:||..|
Zfish   738 APKWTELASVINSCMD---YEPLHRPSFRALIRDLNSL-------YTPDYELLVE---SDTVPSR 789

  Fly   866 SDIPFL--PFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML 928
            ...|.|  .|....     |...:.|.:..:: ::|:|::|:|.|...: ..:|...|.||:|.|
Zfish   790 HRGPGLAGAFESQE-----PTQFQARHLIFLQ-LLGKGNFGSVEKCRYD-PLQDNTGEVVAVKKL 847

  Fly   929 --NTMQVSTDFHREIGIMRTLSHPNIVKFK---YWAEKSHC-IIMEYLQSGSFDIYLRFTAPNLN 987
              :|.:...||.|||.|:|:|.|.|||::|   |.|.:::. ::||:|..||...||.......:
Zfish   848 QHSTAEHLRDFEREIEILRSLQHENIVRYKGVCYSAGRNNLRLVMEFLPFGSLRDYLSKNRERFD 912

  Fly   988 NPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSD-GYYYAK 1051
            :.:|:.:|..|..||.||::...:|||||.|||||:....   |||.||||.:....| .||..:
Zfish   913 HSKLLLYASQICKGMDYLAEKRYVHRDLATRNILVESEFR---VKIGDFGLTKVLPQDKEYYTVR 974

  Fly  1052 SKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEE---PNLVPIQTSQED-------- 1105
            ...:.||.||:||:::..:||..|||||:||.|:|:|:..|:   |..|.::...||
Zfish   975 EPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYSEKSCSPPAVFMEQMGEDKQGQMIVY 1039

  Fly  1106 -FLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSF----ATIVDI 1150
             .::.|:...||..|..||..|:.||:.||...|..||.|    .|:.||
Zfish  1040 HLIDLLKRNYRLPAPDGCPAEIHALMKQCWAPEPADRPLFRDLARTVEDI 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604	55/240 (23%)
		SH2_Jak_family	420..516	CDD:198177	22/108 (20%)
		PTK_Jak_rpt1	584..836	CDD:270633	77/286 (27%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	103/288 (36%)
		TyrKc	894..1151	CDD:197581	102/280 (36%)
jak2a	NP_571168.1	B41	20..247	CDD:214604	55/240 (23%)
		FERM_C_JAK2	243..352	CDD:270141	30/164 (18%)
		SH2_Jak2	352..448	CDD:198242	24/115 (21%)
		PKc_like	509..770	CDD:304357	79/291 (27%)
		Pkinase_Tyr	509..769	CDD:285015	79/290 (27%)
		PTKc_Jak2_rpt2	807..1090	CDD:271107	103/288 (36%)
		TyrKc	812..1084	CDD:197581	99/276 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H114138
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3244
OMA	1	1.010	-	-		QHG47769
OrthoDB	1	1.010	-	-		D38412at33208
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		otm26318
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17279
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.110