DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Hck

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_037317.2	Gene:	Hck / 25734	RGDID:	2785	Length:	524	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	114/433 - (26%)
Similarity:	190/433 - (43%)	Gaps:	70/433 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 WIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDI 805
            :||..|...:.:.:|::    |.|.       ...::|    .:..||...|:.|:.: :.|.:.
  Rat   125 YIPSNYVARVNSLETEE----WFFK-------GISRKD----AERHLLAPGNMLGSFM-IRDSET 173

  Fly   806 CPAPIFETI--MDGWSDDETKRF------------SHHDIFSRLNTIKAEILPNYMPPPEIATNG 856
            .......::  .|....|..|.:            |....||.|.    |::.:|.
  Rat   174 TKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQ----ELVVHYK--------- 225

  Fly   857 TGDETVIDRSDIPFL-PFPRSNMLMVIPLTSEC----RVIYNMENMIGRGHYGTVYKGHLEFNDK 916
            .|.:.:..:..:|.: |.|:.      |...:.    |....||..:|.|.:|.|:......:.|
  Rat   226 KGKDGLCQKLSVPCVSPKPQK------PWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTK 284

  Fly   917 DQPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVKF-KYWAEKSHCIIMEYLQSGSFDIYL 979
                  ||:|.:....:|.: |..|..:|:||.|..:||. ...:::...|:.|::..||...:|
  Rat   285 ------VAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQEPIFIVTEFMAKGSLLDFL 343

  Fly   980 RFTAPNLNN-PRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFAN 1043
            :....:... |:|:.|:..|:.||.::.....|||||.|.||||  :....| ||:|||||:..
  Rat   344 KSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILV--SASLVC-KIADFGLARII- 404

  Fly  1044 SDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLN 1108
            .|..|.|:.....||:|.:||||:...|:..|||||:|:.|.|:.:.|..|  .| ..|..:.:.
  Rat   405 EDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP--YP-GMSNPEVIR 466

  Fly  1109 RLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII 1151
            .|:.|.|:.||.:||:.:|.:|..||...|..||:|..|..::
  Rat   467 ALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQSVL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	18/108 (17%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	88/273 (32%)
		TyrKc	894..1151	CDD:197581	87/259 (34%)
Hck	NP_037317.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..71
		SH3	80..135	CDD:302595	3/9 (33%)
		SH2_Src_HCK	138..241	CDD:198226	20/131 (15%)
		PKc_like	252..522	CDD:304357	88/271 (32%)
		Pkinase_Tyr	260..509	CDD:285015	87/261 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810