DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and FYN

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001357458.1	Gene:	FYN / 2534	HGNCID:	4037	Length:	537	Species:	Homo sapiens

Alignment Length:	480	Identity:	125/480 - (26%)
Similarity:	200/480 - (41%)	Gaps:	96/480 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 LYVTKYDPNS--------------YVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFA 759
            |:|..||..:              .:|::...|....|.....::.:||..|...:.:.:.::
Human    86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEE-- 148

  Fly   760 QLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETK 824
              |.|.       ...::|    .:.|||...|..|..| :.:.:........:|.| |.|.:..
Human   149 --WYFG-------KLGRKD----AERQLLSFGNPRGTFL-IRESETTKGAYSLSIRD-WDDMKGD 198

  Fly   825 RFSHHDIFSRLN-----TIKAE----------------------ILPNYMPPPEIATNGTGDETV 862
            ...|:.|....|     |.:|:                      ::|.:...|.:.      :..
Human   199 HVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLT------DLS 257

  Fly   863 IDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKM 927
            :...|:  ...||.::.::              ..:|.|.:|.|:.|....|.|      ||||.
Human   258 VKTKDV--WEIPRESLQLI--------------KRLGNGQFGEVWMGTWNGNTK------VAIKT 300

  Fly   928 LNTMQVSTD-FHREIGIMRTLSHPNIVK-FKYWAEKSHCIIMEYLQSGSFDIYLR-FTAPNLNNP 989
            |....:|.: |..|..||:.|.|..:|: :...:|:...|:.||:..||...:|: .....|..|
Human   301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLP 365

  Fly   990 RLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKR 1054
            .||..|..:|.||.|:..|..|||||.:.||||   |:|...||:|||||:.. .|..|.|:...
Human   366 NLVDMAAQVAAGMAYIERMNYIHRDLRSANILV---GNGLICKIADFGLARLI-EDNEYTARQGA 426

  Fly  1055 DIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRP 1119
            ..||:|.:|||....||:..|||||:|:.|.|:.::|..|  .|...::| .|.:::.|.|:..|
Human   427 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP--YPGMNNRE-VLEQVERGYRMPCP 488

  Fly  1120 ASCPDFIYDLMQLCWHATPRSRPSF 1144
            ..||..:::||..||...|..||:|
Human   489 QDCPISLHELMIHCWKKDPEERPTF 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	25/140 (18%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	92/262 (35%)
		TyrKc	894..1151	CDD:197581	92/254 (36%)
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939	10/53 (19%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	18/116 (16%)
		PTKc_Fyn	261..534	CDD:270655	95/282 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810