DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and Yes1

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_006245737.1	Gene:	Yes1 / 24884	RGDID:	3977	Length:	541	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	113/376 - (30%)
Similarity:	168/376 - (44%)	Gaps:	59/376 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   781 TLRQEQLLRQKNLDGNILKMLDQD---ICPAPIFETIMDGWSDDETKRFSHH--DIFSRLNTIKA 840
            ::|....:|..|:....::.||..   |.....|:|:     ....|.::.|  .:..:|.|:..
  Rat   195 SIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL-----QKLVKHYTEHADGLCHKLTTVCP 254

  Fly   841 EILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGT 905
            .:.|.        |.|...    |..:||                   |....:|..:|:|.:|.
  Rat   255 TVKPQ--------TQGLAK----DAWEIP-------------------RESLRLEVKLGQGCFGE 288

  Fly   906 VYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREIGIMRTLSHPNIVK-FKYWAEKSHCIIM 967
            |:.|......|      ||||.|  .||.... |.:|..||:.|.|..:|. :...:|:...|:.
  Rat   289 VWMGTWNGTTK------VAIKTLKPGTMMPEA-FLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVT 346

  Fly   968 EYLQSGS-FDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCV 1031
            |::..|| .|.........|..|:||..|..||:||.|:..|..|||||.|.||||   |:....
  Rat   347 EFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLVC 408

  Fly  1032 KISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNL 1096
            ||:|||||:.. .|..|.|:.....||:|.:|||....||:..|||||:|:...|:.::|..|
  Rat   409 KIADFGLARLI-EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVP-- 470

  Fly  1097 VPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATI 1147
            .|...::| .|.:::.|.|:..|..||:.:::||.|||...|..||:|..|
  Rat   471 YPGMVNRE-VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	10/59 (17%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	95/266 (36%)
		TyrKc	894..1151	CDD:197581	94/258 (36%)
Yes1	XP_006245737.1	SH3_Yes	92..149	CDD:212940
		SH2_Src_family	152..251	CDD:199827	11/60 (18%)
		PTKc_Yes	262..540	CDD:270654	99/296 (33%)
		Pkinase_Tyr	275..524	CDD:285015	94/260 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910