DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and Jak2

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_113702.1 Gene:Jak2 / 24514 RGDID:2939 Length:1132 Species:Rattus norvegicus


Alignment Length:1275 Identity:325/1275 - (25%)
Similarity:538/1275 - (42%) Gaps:290/1275 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 ASLTNSSLRSGTSSQSIHTN-------------DGTIRVFNF-----TTGEFERFHPN--MLCEE 69
            |.||.:.: .|||:...|.|             :..::|:.:     ..|::.:| ||  .:.||
  Rat     4 ACLTMTEM-EGTSTSPAHQNGDIPGNANSVKQTEPVLQVYLYHSLGQAEGDYLKF-PNGEYVAEE 66

  Fly    70 ICNTMCRQLGIAPIAQLLYGIREHSTSR---RPSPLVRLDLTWCLPGERLNCQLVYCFRMRFRVP 131
            ||....:..||.|:...::.:.. .|.|   .|:.:..:|       |.....::|  |:||..|
  Rat    67 ICVAASKACGITPVYHNMFALMS-ETERIWYPPNHVFHID-------ESTRHNILY--RIRFYFP 121

  Fly   132 ---------------ELDSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTGLAVMDM 181
                           ...::..|:|.....:|:.|.|:|.....|......|.:::..|:||:||
  Rat   122 HWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDM 186

  Fly   182 LIDDQEQSEDQQAM-RSIEKLYKLYLPPSLWRA----HSFFVGSKIREVFR-------SLKANSL 234
            :...:|:.:...|: .||.  ||.:||..: ||    :......:||..||       ..||   
  Rat   187 MRIAKEKDQTPLAVYNSIS--YKTFLPKCV-RAKIQDYHILTRKRIRYRFRRFIQQFSQCKA--- 245

  Fly   235 SVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLS 299
            :...||..|:..:..|...:.||||..       :|.||  ||.|..:               .:
  Rat   246 TARNLKLKYLINLETLQSAFYTEQFEV-------KESAR--GPSGEEI---------------FA 286

  Fly   300 TLTTNTNSVALGGSGK-KAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEG 363
            |:....|.......|| |.....|...:.:|.. || |.::..:|.|........:.:.|...:|
  Rat   287 TIIITGNGGIQWSRGKHKESETLTEQDLQLYCD-FP-DIIDVSIKQANQECSTESRVVTVHKQDG 349

  Fly   364 IFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEE 428
                                |..|::..:.||..||:|.:..|.||::.....||.....|::.|
  Rat   350 --------------------KVLEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLE 394

  Fly   429 LSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFR 493
            ....:|||||...:::.||.:.|::.|.|::|...:::|.|::                   ||.
  Rat   395 NIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFL-------------------TFA 440

  Fly   494 IVRKD-SQWK---LSYN-NGEHVL-------NSLHEVAHIIQADSPDRYRI--------PASKYD 538
            :.|:: .::|   ::.| |||:.|       :||.::.:..|.::.....|        |....|
  Rat   441 VERENVIEYKHCLITKNENGEYNLSGTKRNFSSLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKD 505

  Fly   539 KPPLLLLLLPKNLKAKKT----DLQLSEAELQRR---NPQIFNP-RTDLQWYPDSISLSDDGMMF 595
            |..||:.         :|    |:|||.. |||.   |..:|:. |.:...:.:|:.......:|
  Rat   506 KSNLLVF---------RTNGVSDVQLSPT-LQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIF 560

  Fly   596 T-MR---GDWIQQSPVKDVSVTMKML-KSDGNFME-FFRLAQTWSLIQSPQFLKLYGLTL-ADPY 653
            . :|   ||:.|   :.:..|.:|:| |:..|:.| ||..|...|.:.....:..||:.: .:..
  Rat   561 KGVRREVGDYGQ---LHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEEN 622

  Fly   654 TMVMEYSRYGPLNKFLHSMPN-VTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPN 717
            .:|.|:.::|.|:.:|....| :.:...|.:...|...||:||:..:||..:...|:.:.:.:..
  Rat   623 ILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDR 687

  Fly   718 S-----YVLDAKISDPG-----YPRPYRESDSPWIP---VKYYRNLQAAKTDQFAQLWAFATTIY 769
            .     ::   |:||||     .|:...:...||:|   ::..:||..| ||:    |:|.||::
  Rat   688 KTGNPPFI---KLSDPGISITVLPKDILQERIPWVPPECIENPKNLTLA-TDK----WSFGTTLW 744

  Fly   770 EIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAP-------IFETIMDGWSDDETKRFS 827
            ||.|...:.||.|..::.|:...         |:...|||       :..|.|| :..|....| 
  Rat   745 EICSGGDKPLSALDSQRKLQFYE---------DKHQLPAPKWTELANLINTCMD-YEPDFRPAF- 798

  Fly   828 HHDIFSRLNTIKAEILPNY--------MPPPEIATNGTG------DETVIDRSDIPFLPFPRSNM 878
             ..:...||::   ..|:|        :|...|...|..      |.|..:...:.||       
  Rat   799 -RAVIRDLNSL---FTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFL------- 852

  Fly   879 LMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREI 941
                             ..:|:|::|:|.....: ..:|...|.||:|.|  :|.:...||.|||
  Rat   853 -----------------QQLGKGNFGSVEMCRYD-PLQDNTGEVVAVKKLQHSTEEHLRDFEREI 899

  Fly   942 GIMRTLSHPNIVKFK---YWAEKSHC-IIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGM 1002
            .|:::|.|.||||:|   |.|.:.:. :|||||..||...||:.....:::.:|:.:...|..||
  Rat   900 EILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGM 964

  Fly  1003 KYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSD-GYYYAKSKRDIPIRWYSPEAI 1066
            :||.....||||||.|||||::.   :.|||.||||.:....| .||..|...:.||.||:||::
  Rat   965 EYLGTKRYIHRDLATRNILVENE---NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL 1026

  Fly  1067 STCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQE------------DFLNRLQSGERLNRP 1119
            :..:||..|||||:||.|:|:|:..|:....|::..:.            ..:..|::..||.||
  Rat  1027 TESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRP 1091

  Fly  1120 ASCPDFIYDLMQLCWHATPRSRPSFATI---VDIITREVA 1156
            ..|||.||.:|..||:.....||||..:   ||.|...:|
  Rat  1092 EGCPDEIYVIMTECWNNNVNQRPSFRDLSLRVDQIRDSMA 1131

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604 59/269 (22%)
SH2_Jak_family 420..516 CDD:198177 25/107 (23%)
PTK_Jak_rpt1 584..836 CDD:270633 67/279 (24%)
PTKc_Jak_rpt2 886..1155 CDD:270634 103/290 (36%)
TyrKc 894..1151 CDD:197581 102/278 (37%)
Jak2NP_113702.1 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..239 57/249 (23%)
FERM_F1 39..134 CDD:408179 22/105 (21%)
FERM_F2 143..261 CDD:408177 32/123 (26%)
FERM_C_JAK2 266..386 CDD:270141 36/165 (22%)
SH2_Jak2 386..482 CDD:198242 26/114 (23%)
PTK_Jak2_rpt1 545..806 CDD:270663 67/283 (24%)
PTKc_Jak2_rpt2 844..1127 CDD:271107 104/310 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 251 1.000 Inparanoid score I3138
OMA 1 1.010 - - QHG47769
OrthoDB 1 1.010 - - D38412at33208
OrthoFinder 1 1.000 - - FOG0001105
OrthoInspector 1 1.000 - - otm44657
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45807
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X669
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1010.080

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