DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and FRK

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens

Alignment Length:	448	Identity:	126/448 - (28%)
Similarity:	203/448 - (45%)	Gaps:	104/448 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 WIPVKYY---RNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLD 802
            :||..|.   |:||       |:.|.|...       .:.|    .::|||..:|..|:.| :.:
Human    99 YIPSNYVAEDRSLQ-------AEPWFFGAI-------GRSD----AEKQLLYSENKTGSFL-IRE 144

  Fly   803 QDICPAPIFETIMDG---------WSDDETKRFSHHDIFSRLNTIKAEILPNY------------ 846
            .:........:::||         ..|:.....:...|||.||    |.:.:|
Human   145 SESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLN----EFVSHYTKTSDGLCVKLG 205

  Fly   847 -------MPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYG 904
                   :|.|...:..|.|:..|||:.|..|                        ..:|.|.:|
Human   206 KPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLL------------------------KRLGSGQFG 246

  Fly   905 TVYKGHLEFNDKDQPREQVAIKMLNTMQVS-TDFHREIGIMRTLSHPNIVKFKYWA----EKSHC 964
            .|::|  .:|:    ...||:|.|....:. .||.||..||:.|.||.:::.  :|    |....
Human   247 EVWEG--LWNN----TTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQL--YAVCTLEDPIY 303

  Fly   965 IIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDG 1028
            ||.|.::.||...||: .|...::..:.|..|..:|:||.||.....|||||||||:||   |:.
Human   304 IITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLV---GEH 365

  Fly  1029 DCVKISDFGLAQF--ANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRG 1091
            :..|::|||||:.  .:::..|.::.:..:|::|.:||||.:.:||..|||||:|:.|:|:.:.|
Human   366 NIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYG 430

  Fly  1092 EEP--NLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATI 1147
            :.|  .:...|..|     .|....||.:|::||...|::|..||:|.|:.||:|.|:
Human   431 KMPYSGMTGAQVIQ-----MLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	22/106 (21%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	91/272 (33%)
		TyrKc	894..1151	CDD:197581	91/264 (34%)
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779	2/4 (50%)
		SH2_Src_Frk	112..207	CDD:199831	21/117 (18%)
		PTKc_Frk_like	225..494	CDD:270653	97/299 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810