DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and FGR

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001036194.1	Gene:	FGR / 2268	HGNCID:	3697	Length:	529	Species:	Homo sapiens

Alignment Length:	531	Identity:	128/531 - (24%)
Similarity:	207/531 - (38%)	Gaps:	118/531 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   664 PLNKFLHSMPNVTLHC-------LLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNS--- 718
            |.:.|.| :||.:...       .||  .|.:||:..:.           ..|::..||..:
Human    43 PASSFAH-IPNYSNFSSQAINPGFLD--SGTIRGVSGIG-----------VTLFIALYDYEARTE 93

  Fly   719 -----------YVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIF 772
                       ::|:....|....|......:..||..|...:.:.:.::    |.|...
Human    94 DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEE----WYFGKI----- 149

  Fly   773 SRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFS---- 833
              .::|    .:.|||...|..|..| :.:.:........:|.| |.........|:.|..
Human   150 --GRKD----AERQLLSPGNPQGAFL-IRESETTKGAYSLSIRD-WDQTRGDHVKHYKIRKLDMG 206

  Fly   834 --------RLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLT----- 885
                    :.|::: |::.:||...:...|                       |::.|.|
Human   207 GYYITTRVQFNSVQ-ELVQHYMEVNDGLCN-----------------------LLIAPCTIMKPQ 247

  Fly   886 ---------SECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTD-FHRE 940
                     ...|....:|..:|.|.:|.|:.|....:.|      ||:|.|....:|.. |..|
Human   248 TLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK------VAVKTLKPGTMSPKAFLEE 306

  Fly   941 IGIMRTLSHPNIVK-FKYWAEKSHCIIMEYLQSGS-FDIYLRFTAPNLNNPRLVSFALDIANGMK 1003
            ..:|:.|.|..:|: :...:|:...|:.|::..|| .|........:|..|:||..|..:|.||.
Human   307 AQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371

  Fly  1004 YLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAIST 1068
            |:..|..|||||.|.||||   |:....||:|||||:....|.|...:..: .||:|.:|||...
Human   372 YMERMNYIHRDLRAANILV---GERLACKIADFGLARLIKDDEYNPCQGSK-FPIKWTAPEAALF 432

  Fly  1069 CRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLC 1133
            .||:..|||||:|:.|.|:.::|..|  .|....:| .|.:::.|..:..|..||..:|:.|:..
Human   433 GRFTIKSDVWSFGILLTELITKGRIP--YPGMNKRE-VLEQVEQGYHMPCPPGCPASLYEAMEQT 494

  Fly  1134 WHATPRSRPSF 1144
            |...|..||:|
Human   495 WRLDPEERPTF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	33/204 (16%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	87/262 (33%)
		TyrKc	894..1151	CDD:197581	86/254 (34%)
FGR	NP_001036194.1	SH3	80..137	CDD:327375	9/56 (16%)
		SH2_Src_Fgr	140..240	CDD:198230	20/140 (14%)
		PKc_like	267..514	CDD:328722	85/252 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810