DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Tec

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001106931.1	Gene:	Tec / 21682	MGIID:	98662	Length:	630	Species:	Mus musculus

Alignment Length:	498	Identity:	136/498 - (27%)
Similarity:	215/498 - (43%)	Gaps:	93/498 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 LVRGMHY--LEDNKIIHNYIRCSNLYVTK-YDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYR 748
            |.||..|  ||.|.:  ::.|..:.|.:: |.|::||...|.:
Mouse   199 LERGQEYIILEKNDL--HWWRARDKYGSEGYIPSNYVTGKKSN---------------------- 239

  Fly   749 NLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFET 813
            ||     ||           ||.:.|   :.:..:.|||||.::.:|..  |:.....|.....:
Mouse   240 NL-----DQ-----------YEWYCR---NTNRSKAEQLLRTEDKEGGF--MVRDSSQPGLYTVS 283

  Fly   814 IMDGWSDDETKRFSHHDIFSRLNTIKAEILPN---YMPPPEIAT----NGTGDETVIDRSDIPFL 871
            :...:..:.:..|.|:.|.....:.|...|..   :...|||..    |..|   ::.|     |
Mouse   284 LYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAG---LVTR-----L 340

  Fly   872 PFPRSNMLMVIPLT----------SECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIK 926
            .:|.|......|.|          :...:.:..|  :|.|.:|.|..|      |.:.:.:||||
Mouse   341 RYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRE--LGSGLFGVVRLG------KWRAQYKVAIK 397

  Fly   927 MLNT-MQVSTDFHREIGIMRTLSHPNIVKFKYWA---EKSHCIIMEYLQSGSFDIYLRFTAPNLN 987
            .:.. .....||..|..:|..|:||.:|:. |..   :|...|:.|:::.|....:||....:.:
Mouse   398 AIREGAMCEEDFIEEAKVMMKLTHPKLVQL-YGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFS 461

  Fly   988 NPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKS 1052
            ...|:|...|:..||:||.....|||||||||.||:..|   .||:||||:|::. .|..|.:.|
Mouse   462 RDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG---VVKVSDFGMARYV-LDDQYTSSS 522

  Fly  1053 KRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLN 1117
            ....|::|..||..:..||||.|||||:||.::|:|:.|..|.   .:.:..:.:..:..|.||:
Mouse   523 GAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPF---EKNTNYEVVTMVTRGHRLH 584

  Fly  1118 RPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVT 1160
            ||.....::|::|..||...|..||||..::..|...|..:.|
Mouse   585 RPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEET 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	32/151 (21%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	89/272 (33%)
		TyrKc	894..1151	CDD:197581	88/260 (34%)
Tec	NP_001106931.1	PH_Btk	7..148	CDD:269944
		SH3_Tec	182..236	CDD:212838	13/38 (34%)
		SH2_Tec_Itk	239..346	CDD:198259	28/157 (18%)
		PTKc_Tec_Rlk	364..623	CDD:270685	89/274 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900