DRSC/TRiP Functional Genomics Resources

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Protein Alignment hop and Lck

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_001155904.1 Gene:Lck / 16818 MGIID:96756 Length:520 Species:Mus musculus


Alignment Length:485 Identity:132/485 - (27%)
Similarity:203/485 - (41%) Gaps:114/485 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   716 PNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLS 780
            |.::|..|...:|          .||    :::||.                        ::|  
Mouse   123 PFNFVAKANSLEP----------EPW----FFKNLS------------------------RKD-- 147

  Fly   781 TLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPN 845
              .:.|||...|..|:.|  :.:....|..|...:..:..::.:...|:.|.:..|       ..
Mouse   148 --AERQLLAPGNTHGSFL--IRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDN-------GG 201

  Fly   846 YMPPPEIATNGTGDE------------TVIDR---SDIPFLPF-------PRSNMLMVIPLTSEC 888
            :...|.|...|..|.            |.:.|   :..|..|:       ||..:.:|       
Mouse   202 FYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLV------- 259

  Fly   889 RVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNI 952
                   ..:|.|.:|.|:.|:...:.|      ||:|.|....:|.| |..|..:|:.|.||.:
Mouse   260 -------ERLGAGQFGEVWMGYYNGHTK------VAVKSLKQGSMSPDAFLAEANLMKQLQHPRL 311

  Fly   953 VK-FKYWAEKSHCIIMEYLQSGSFDIYLRFTAPN---LNNPRLVSFALDIANGMKYLSDMGLIHR 1013
            |: :....::...||.||:::||...:|:  .|:   ||..:|:..|..||.||.::.:...|||
Mouse   312 VRLYAVVTQEPIYIITEYMENGSLVDFLK--TPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHR 374

  Fly  1014 DLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVW 1078
            ||.|.||||   .|....||:|||||:.. .|..|.|:.....||:|.:||||:...|:..||||
Mouse   375 DLRAANILV---SDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVW 435

  Fly  1079 SYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPS 1143
            |:|:.|.|:.:.|..|  .|..|:.| .:..|:.|.|:.||.:||:.:|.||.|||...|..||:
Mouse   436 SFGILLTEIVTHGRIP--YPGMTNPE-VIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPT 497

  Fly  1144 FATIVDIITREVATKVTHPTDGHQSPPNQP 1173
            |..:     |.|.......|:|...|  ||
Mouse   498 FDYL-----RSVLDDFFTATEGQYQP--QP 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604
SH2_Jak_family 420..516 CDD:198177
PTK_Jak_rpt1 584..836 CDD:270633 19/119 (16%)
PTKc_Jak_rpt2 886..1155 CDD:270634 95/273 (35%)
TyrKc 894..1151 CDD:197581 94/261 (36%)
LckNP_001155904.1 SH3_Lck 76..129 CDD:212938 2/5 (40%)
SH2_Src_Lck 134..234 CDD:198225 22/150 (15%)
PTKc_Lck_Blk 248..511 CDD:270652 99/296 (33%)
Pkinase_Tyr 256..505 CDD:285015 96/282 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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