| Sequence 1: | NP_511119.2 | Gene: | hop / 32080 | FlyBaseID: | FBgn0004864 | Length: | 1177 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001041642.1 | Gene: | Jak2 / 16452 | MGIID: | 96629 | Length: | 1132 | Species: | Mus musculus |
| Alignment Length: | 1275 | Identity: | 321/1275 - (25%) |
|---|---|---|---|
| Similarity: | 537/1275 - (42%) | Gaps: | 290/1275 - (22%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 25 ASLTNSSLRSGTSSQSIHTN-------------DGTIRVFNF-----TTGEFERFHPN--MLCEE 69
Fly 70 ICNTMCRQLGIAPIAQLLYGIREHSTSR---RPSPLVRLDLTWCLPGERLNCQLVYCFRMRFRVP 131
Fly 132 ---------------ELDSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTGLAVMDM 181
Fly 182 LIDDQEQSEDQQAM-RSIEKLYKLYLPPSLWRA----HSFFVGSKIREVFR-------SLKANSL 234
Fly 235 SVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLS 299
Fly 300 TLTTNTNSVALGGSGK-KAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEG 363
Fly 364 IFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEE 428
Fly 429 LSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFR 493
Fly 494 IVRKD-SQWK---LSYN-NGEHVL-------NSLHEVAHIIQADSPDRYRI--------PASKYD 538
Fly 539 KPPLLLLLLPKNLKAKKT----DLQLSEAELQRR---NPQIFNP-RTDLQWYPDSISLSDDGMMF 595
Fly 596 T-MR---GDWIQQSPVKDVSVTMKML-KSDGNFME-FFRLAQTWSLIQSPQFLKLYGLTL-ADPY 653
Fly 654 TMVMEYSRYGPLNKFLHSMPN-VTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPN 717
Fly 718 -----SYVLDAKISDPG-----YPRPYRESDSPWIP---VKYYRNLQAAKTDQFAQLWAFATTIY 769
Fly 770 EIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAP-------IFETIMDGWSDDETKRFS 827
Fly 828 HHDIFSRLNTIKAEILPNY--------MPPPEIATNGTG------DETVIDRSDIPFLPFPRSNM 878
Fly 879 LMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREI 941
Fly 942 GIMRTLSHPNIVKFK---YWAEKSHC-IIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGM 1002
Fly 1003 KYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSD-GYYYAKSKRDIPIRWYSPEAI 1066
Fly 1067 STCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQE------------DFLNRLQSGERLNRP 1119
Fly 1120 ASCPDFIYDLMQLCWHATPRSRPSFATI---VDIITREVA 1156 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| hop | NP_511119.2 | B41 | 39..259 | CDD:214604 | 58/269 (22%) |
| SH2_Jak_family | 420..516 | CDD:198177 | 24/107 (22%) | ||
| PTK_Jak_rpt1 | 584..836 | CDD:270633 | 66/279 (24%) | ||
| PTKc_Jak_rpt2 | 886..1155 | CDD:270634 | 104/290 (36%) | ||
| TyrKc | 894..1151 | CDD:197581 | 103/278 (37%) | ||
| Jak2 | NP_001041642.1 | Interaction with cytokine/interferon/growth hormone receptors | 1..239 | 55/249 (22%) | |
| FERM_F1 | 39..134 | CDD:408179 | 22/105 (21%) | ||
| FERM_F2 | 143..261 | CDD:408177 | 31/123 (25%) | ||
| FERM_C_JAK2 | 266..386 | CDD:270141 | 36/165 (22%) | ||
| SH2_Jak2 | 386..482 | CDD:198242 | 25/114 (22%) | ||
| PTK_Jak2_rpt1 | 545..806 | CDD:270663 | 66/283 (23%) | ||
| PTKc_Jak2_rpt2 | 844..1127 | CDD:271107 | 105/310 (34%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0197 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 247 | 1.000 | Inparanoid score | I3247 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S4806 |
| OMA | 1 | 1.010 | - | - | QHG47769 | |
| OrthoDB | 1 | 1.010 | - | - | D38412at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001105 | |
| OrthoInspector | 1 | 1.000 | - | - | otm42587 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR45807 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R17279 |
| SonicParanoid | 1 | 1.000 | - | - | X669 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 14 | 13.920 | |||||