DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and CSK

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001120662.1	Gene:	CSK / 1445	HGNCID:	2444	Length:	450	Species:	Homo sapiens

Alignment Length:	474	Identity:	127/474 - (26%)
Similarity:	195/474 - (41%)	Gaps:	121/474 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 VTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQL--WAFATTIYEIFS 773
            ||| |||.|....|:...|.           ||..|.:..:..|......|  |.......|
Human    41 VTK-DPNWYKAKNKVGREGI-----------IPANYVQKREGVKAGTKLSLMPWFHGKITRE--- 90

  Fly   774 RCKEDLSTLRQEQLL-----------RQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFS 827
                     :.|:||           ...|..|      |..:|.:      .||       :..
Human    91 ---------QAERLLYPPETGLFLVRESTNYPG------DYTLCVS------CDG-------KVE 127

  Fly   828 HHDIF---SRLNTIKAEILPNYMPPPEIATNGTGD--------------ETVIDRSDIPFLPFPR 875
            |:.|.   |:|:..:.....|.|   ::..:.|.|              |..:...|    .|.|
Human   128 HYRIMYHASKLSIDEEVYFENLM---QLVEHYTSDADGLCTRLIKPKVMEGTVAAQD----EFYR 185

  Fly   876 SNMLMVIPLTSECRVIYNMENM-----IGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVST 935
            |...:            ||:.:     ||:|.:|.|..|       |....:||:|.:.....:.
Human   186 SGWAL------------NMKELKLLQTIGKGEFGDVMLG-------DYRGNKVAVKCIKNDATAQ 231

  Fly   936 DFHREIGIMRTLSHPNIVKF--KYWAEKSHC-IIMEYLQSGSFDIYLRFTAPN-LNNPRLVSFAL 996
            .|..|..:|..|.|.|:|:.  ....||... |:.||:..||...|||....: |....|:.|:|
Human   232 AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296

  Fly   997 DIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWY 1061
            |:...|:||.....:||||||||:||   .:.:..|:|||||.:.|:|     .:....:|::|.
Human   297 DVCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASS-----TQDTGKLPVKWT 353

  Fly  1062 SPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEP-NLVPIQTSQEDFLNRLQSGERLNRPASCPDF 1125
            :|||:...:||:.|||||:|:.|:|::|.|..| ..:|:    :|.:.|::.|.:::.|..||..
Human   354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL----KDVVPRVEKGYKMDAPDGCPPA 414

  Fly  1126 IYDLMQLCWHATPRSRPSF 1144
            :|::|:.|||.....||||
Human   415 VYEVMKNCWHLDAAMRPSF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	28/140 (20%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	89/269 (33%)
		TyrKc	894..1151	CDD:197581	88/261 (34%)
CSK	NP_001120662.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41241	9..70		12/40 (30%)
		SH3_CSK	11..67	CDD:212703	12/37 (32%)
		SH2_csk_like	78..175	CDD:198190	20/130 (15%)
		PTKc_Csk	188..443	CDD:133213	89/277 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810