DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and Frk

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001153016.1	Gene:	Frk / 14302	MGIID:	103265	Length:	512	Species:	Mus musculus

Alignment Length:	453	Identity:	129/453 - (28%)
Similarity:	198/453 - (43%)	Gaps:	114/453 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 WIPVKYY---RNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNI----- 797
            :||..|.   |:||       |:.|.|..     ..|..      .::|||..:|..|..
Mouse   106 YIPSNYVAEDRSLQ-------AEPWFFGA-----IKRAD------AEKQLLYSENQTGAFLIRES 152

  Fly   798 --------LKMLDQDICPAPIFETIMDGWSDDETKRF-SHHDIFSRLN-------------TIKA 840
                    |.:||:.:........:      ||...| :...:||.||             .:|.
Mouse   153 ESQKGDFSLSVLDEGVVKHYRIRRL------DEGGFFLTRRKVFSTLNEFVNYYTTTSDGLCVKL 211

  Fly   841 E--ILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHY 903
            |  .|...:|.|...:..|.|:..|||:.|..|                        ..:|.|.:
Mouse   212 EKPCLKIQVPTPFDLSYKTADQWEIDRNSIQLL------------------------KRLGSGQF 252

  Fly   904 GTVYKGHLEFNDKDQPREQVAIKMLNTMQVS-TDFHREIGIMRTLSHPNIVKFKYWA----EKSH 963
            |.|::|  .:|:    ...||:|.|....:. .||.||..||::|.||.:::.  :|    |...
Mouse   253 GEVWEG--LWNN----TTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQL--YAVCTLEDPI 309

  Fly   964 CIIMEYLQSGSFDIYLRFTAPNLNNPRL-----VSFALDIANGMKYLSDMGLIHRDLAARNILVD 1023
            .||.|.::.||...||:    |....::     |..|..:|:||.||.....|||||||||:||
Mouse   310 YIITELMRHGSLQEYLQ----NDGGSKIHLIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLV- 369

  Fly  1024 HNGDGDCVKISDFGLAQF--ANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFE 1086
              |:.:..|::|||||:.  .:::..|.:|.:..:|::|.:||||.|.:||..|||||:|:.|:|
Mouse   370 --GEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYE 432

  Fly  1087 MFSRGEEP--NLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATI 1147
            :.:.|:.|  .:...|..|     .|....||.:|::||...|.:|..||:..|:.||:|.|:
Mouse   433 IITYGKMPYSGMTGAQVIQ-----MLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	23/111 (21%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	92/276 (33%)
		TyrKc	894..1151	CDD:197581	92/268 (34%)
Frk	NP_001153016.1	SH3_Src_like	54..111	CDD:212779	2/4 (50%)
		SH2_Src_Frk	119..214	CDD:199831	22/118 (19%)
		PTKc_Frk_like	232..501	CDD:270653	98/303 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810