DRSC/TRiP Functional Genomics Resources

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Protein Alignment hop and Fgr

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_034338.3 Gene:Fgr / 14191 MGIID:95527 Length:517 Species:Mus musculus


Alignment Length:436 Identity:117/436 - (26%)
Similarity:185/436 - (42%) Gaps:89/436 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   741 WIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDI 805
            ::|..|...:.:.:.::    |.|...       .::|    .:.|||...|..|..| :.:.:.
Mouse   115 YVPSNYVAPVDSIQAEE----WYFGKI-------SRKD----AERQLLSSGNPQGAFL-IRESET 163

  Fly   806 CPAPIFETIMDGWSDDETKRFSHHDIFSRLN------TIKA------EILPNYM----------- 847
            .......:|.| |..:......|:.| .:|:      |.:|      :::.:||           
Mouse   164 TKGAYSLSIRD-WDQNRGDHIKHYKI-RKLDTGGYYITTRAQFDSIQDLVRHYMEVNDGLCYLLT 226

  Fly   848 -----PPPEIATNGTG-DETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTV 906
                 ..|:  |.|.. |...|||:.|.                        :|..:|.|.:|.|
Mouse   227 APCTTTKPQ--TLGLAKDAWEIDRNSIA------------------------LERRLGTGCFGDV 265

  Fly   907 YKGHLEFNDKDQPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVK-FKYWAEKSHCIIMEY 969
            :.|....:.|      ||:|.|....:|.. |..|..||:.|.|..:|: :...:|:...|:.|:
Mouse   266 WLGTWNCSTK------VAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIYIVTEF 324

  Fly   970 LQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKI 1033
            :..||...:|: ....||..|.||..|..:|.||.|:..|..|||||.|.||||   |:....||
Mouse   325 MCYGSLLDFLKDREGQNLMLPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILV---GEYLICKI 386

  Fly  1034 SDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVP 1098
            :|||||:.. .|..|..:.....||:|.:|||....||:..|||||:|:.|.|:.::|..|  .|
Mouse   387 ADFGLARLI-EDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVP--YP 448

  Fly  1099 IQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSF 1144
            ...::| .|.:::.|..:..|..||..:|::|:..|...|..||:|
Mouse   449 GMNNRE-VLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTF 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604
SH2_Jak_family 420..516 CDD:198177
PTK_Jak_rpt1 584..836 CDD:270633 16/94 (17%)
PTKc_Jak_rpt2 886..1155 CDD:270634 88/262 (34%)
TyrKc 894..1151 CDD:197581 88/254 (35%)
FgrNP_034338.3 SH3 68..125 CDD:388381 2/9 (22%)
Interaction with CLNK. /evidence=ECO:0000269|PubMed:16439675 102..103
SH2_Src_Fgr 128..228 CDD:198230 19/117 (16%)
PKc_like 255..502 CDD:389743 87/252 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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