DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and Blk

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_031575.2 Gene:Blk / 12143 MGIID:88169 Length:499 Species:Mus musculus


Alignment Length:437 Identity:117/437 - (26%)
Similarity:189/437 - (43%) Gaps:79/437 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   741 WIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDI 805
            ::|..:...::..:.::    |.|.|.       .::|    .:.|||...|..|:.|       
Mouse   101 YVPSNFVAPVETLEVEK----WFFRTI-------SRKD----AERQLLAPMNKAGSFL------- 143

  Fly   806 CPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPF 870
                    |.:..|:......|..||     |.:.|::.:|    :|.:...|...:..|...|.
Mouse   144 --------IRESESNKGAFSLSVKDI-----TTQGEVVKHY----KIRSLDNGGYYISPRITFPT 191

  Fly   871 LP-----FPRSNMLMVIPLTSEC-----------------RVIYNMENMIGRGHYGTVYKGHLEF 913
            |.     :.:....:...||..|                 |....:...:|.|.:|.|:.|:.:.
Mouse   192 LQALVQHYSKKGDGLCQKLTLPCVNLAPKNLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKN 256

  Fly   914 NDKDQPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVK-FKYWAEKSHCIIMEYLQSGSFD 976
            |.|      ||||.|....:|.: |..|..:|:||.|..:|: :.....:...|:.||:..|...
Mouse   257 NMK------VAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLL 315

  Fly   977 IYLRF-TAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQ 1040
            .:|:. ....|:.|||:..:..:|.||.|:..|..|||||.|.||||   .:..|.||:|||||:
Mouse   316 DFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILV---SETLCCKIADFGLAR 377

  Fly  1041 FANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQED 1105
            ..:|:  |.|:.....||:|.:||||....|:..:||||:||.|.|:.:.|..|  .| ..|..:
Mouse   378 IIDSE--YTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVP--YP-GMSNPE 437

  Fly  1106 FLNRLQSGERLNRPASCPDFIY-DLMQLCWHATPRSRPSFATIVDII 1151
            .:..|:.|.|:..|.:||..:| |::..||...|..||:|..:..::
Mouse   438 VIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVL 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604
SH2_Jak_family 420..516 CDD:198177
PTK_Jak_rpt1 584..836 CDD:270633 16/94 (17%)
PTKc_Jak_rpt2 886..1155 CDD:270634 91/287 (32%)
TyrKc 894..1151 CDD:197581 89/260 (34%)
BlkNP_031575.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34
SH3 56..109 CDD:302595 1/7 (14%)
SH2_Src_Blk 114..213 CDD:198234 25/137 (18%)
PKc_like 227..490 CDD:304357 90/272 (33%)
Pkinase_Tyr 235..484 CDD:285015 89/262 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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