DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and Abl2

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_033725.2	Gene:	Abl2 / 11352	MGIID:	87860	Length:	1182	Species:	Mus musculus

Alignment Length:	616	Identity:	161/616 - (26%)
Similarity:	258/616 - (41%)	Gaps:	137/616 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 IQSPQFLKLYGLTLADPYTMVMEYSRYGPLNKFLHSMPNV-TLH-----CLLDLMHG-------- 686
            :|.||...:.|.:.|.|     ...|..|..:...:..|| |.|     |:.|...|
Mouse    14 LQQPQPRGIRGSSAARP-----SGRRRDPAGRTADAGFNVFTQHDHFASCVEDGFEGDKTGGSSP 73

  Fly   687 --LVRGMHYLEDNKIIHNYIRCSN----LYVTKYDPNSYVL----------------DAKISDPG 729
              |.|......:::.::..||.|:    |..|:.|||.:|.                ..|:...|
Mouse    74 EVLHRPFGCDAESQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLG 138

  Fly   730 YPRPYRESD------SPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKED--LSTLRQEQ 786
            |.:....|:      ..|:|..|...:.:.:...    |.....     ||...:  ||:|
Mouse   139 YNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS----WYHGPV-----SRSAAEYLLSSL---- 190

  Fly   787 LLRQKNLDGNILKMLDQDICPAPIFETI-MDGWSDDETKRFSHHDI------------FSRLNTI 838
                  ::|:.| :.:.:..|..:..:: .:|       |..|:.|            .||.:|:
Mouse   191 ------INGSFL-VRESESSPGQLSISLRYEG-------RVYHYRINTTTDSKVYVTAESRFSTL 241

  Fly   839 KAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSN---MLMVIPLTSEC---RVIYNMENM 897
             ||::.::      :|...|..|.:      ..|.|:.|   :..|.|:..:.   |....|::.
Mouse   242 -AELVHHH------STVADGLVTTL------HYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHK 293

  Fly   898 IGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREIGIMRTLSHPNIVKF--KYW 958
            :|.|.||.||.|..:     :....||:|.|  :||:|. :|.:|..:|:.:.|||:|:.  ...
Mouse   294 LGGGQYGEVYVGVWK-----KYSLTVAVKTLKEDTMEVE-EFLKEAAVMKEIKHPNLVQLLGVCT 352

  Fly   959 AEKSHCIIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILV 1022
            .|....|:.||:..|:...||| .:...:....|:..|..|::.|:||.....|||||||||.||
Mouse   353 LEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 417

  Fly  1023 DHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEM 1087
               |:...||::||||::....| .|.|.:....||:|.:||:::...||..||||::||.|:|:
Mouse   418 ---GENHVVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEI 478

  Fly  1088 FSRGEEPNLVP-IQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDI- 1150
            .:.|..|  .| |..||  ..:.|:.|.|:.:|..||..:|:||:.||..:|..|||||.....
Mouse   479 ATYGMSP--YPGIDLSQ--VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF 539

  Fly  1151 --------ITREVATKVTHPTDGHQSPPNQP 1173
                    |:.|||.::..........|..|
Mouse   540 ETMFHDSSISEEVAEELGRTASSSSVVPYLP 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	48/256 (19%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	97/286 (34%)
		TyrKc	894..1151	CDD:197581	95/271 (35%)
Abl2	NP_033725.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		8/32 (25%)
		CAP	2..106		21/96 (22%)
		SH3_Abl	111..164	CDD:212784	8/52 (15%)
		SH2_ABL	169..262	CDD:198189	21/132 (16%)
		PTKc_Abl	281..543	CDD:270645	96/275 (35%)
		STYKc	288..539	CDD:214568	95/264 (36%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..642
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..674
		Nuclear localization signal. /evidence=ECO:0000255	659..661
		F-actin-binding	695..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1059
		F-actin-binding	1020..1182
		FABD	1063..1182	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910