DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and Abl1

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:NP_001106174.1 Gene:Abl1 / 11350 MGIID:87859 Length:1142 Species:Mus musculus


Alignment Length:368 Identity:116/368 - (31%)
Similarity:180/368 - (48%) Gaps:53/368 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   833 SRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSEC------RVI 891
            ||.||: ||::.::      :|...|..|.:      ..|.|:.|...:..::...      |..
Mouse   209 SRFNTL-AELVHHH------STVADGLITTL------HYP
APKRNKPTIYGVSPNYDKWEMERTD 260

  Fly   892 YNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREIGIMRTLSHPNIVK 954
            ..|::.:|.|.||.||:|..:     :....||:|.|  :||:|. :|.:|..:|:.:.|||:|:
Mouse   261 ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKEDTMEVE-EFLKEAAVMKEIKHPNLVQ 319

  Fly   955 F--KYWAEKSHCIIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLA 1016
            .  ....|....||.|::..|:...||| .....::...|:..|..|::.|:||.....||||||
Mouse   320 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLA 384

  Fly  1017 ARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYG 1081
            |||.||   |:...||::||||::....| .|.|.:....||:|.:||:::..:||..||||::|
Mouse   385 ARNCLV---GENHLVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFG 445

  Fly  1082 VTLFEMFSRGEEPNLVP-IQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFA 1145
            |.|:|:.:.|..|  .| |..||  ....|:...|:.||..||:.:|:||:.||...|..|||||
Mouse   446 VLLWEIATYGMSP--YPGIDLSQ--VYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFA 506

  Fly  1146 -------------TIVDIITREVATKVTHPTDGHQ-SPPNQPT 1174
                         :|.|.:.:|:..:.|....|.. ..|..||
Mouse   507 EIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPT 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604
SH2_Jak_family 420..516 CDD:198177
PTK_Jak_rpt1 584..836 CDD:270633 2/2 (100%)
PTKc_Jak_rpt2 886..1155 CDD:270634 98/293 (33%)
TyrKc 894..1151 CDD:197581 97/275 (35%)
Abl1NP_001106174.1 SH3_Abl 84..137 CDD:212784
SH2_ABL 142..235 CDD:198189 9/38 (24%)
PTKc_Abl 254..516 CDD:270645 96/275 (35%)
Pkinase_Tyr 261..512 CDD:285015 95/264 (36%)
FABD 1018..1142 CDD:197885
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.